ENSMUSG00000061436


Mus musculus

Features
Gene ID: ENSMUSG00000061436
  
Biological name :Hipk2
  
Synonyms : Hipk2 / homeodomain interacting protein kinase 2 / Q9QZR5
  
Possible biological names infered from orthology : Q9H2X6
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B1
Gene start: 38694390
Gene end: 38876165
  
Corresponding Affymetrix probe sets: 10544114 (MoGene1.0st)   1424863_a_at (Mouse Genome 430 2.0 Array)   1424864_at (Mouse Genome 430 2.0 Array)   1425983_x_at (Mouse Genome 430 2.0 Array)   1428433_at (Mouse Genome 430 2.0 Array)   1429566_a_at (Mouse Genome 430 2.0 Array)   1432523_at (Mouse Genome 430 2.0 Array)   1448631_a_at (Mouse Genome 430 2.0 Array)   1456022_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125572
Ensembl peptide - ENSMUSP00000124133
Ensembl peptide - ENSMUSP00000125150
Ensembl peptide - ENSMUSP00000125500
NCBI entrez gene - 15258     See in Manteia.
MGI - MGI:1314872
RefSeq - XM_006505603
RefSeq - NM_001136065
RefSeq - NM_001294143
RefSeq - NM_001294144
RefSeq - NM_010433
RefSeq - XM_006505602
RefSeq Peptide - NP_001129537
RefSeq Peptide - NP_001281072
RefSeq Peptide - NP_001281073
RefSeq Peptide - NP_034563
swissprot - A0A0R4J202
swissprot - Q5D0E9
swissprot - Q9QZR5
swissprot - A0A0R4J204
Ensembl - ENSMUSG00000061436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIPK2ENSGALG00000012792Gallus gallus
 HIPK2ENSG00000064393Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hipk1 / O88904 / Homeodomain-interacting protein kinase 1 / Q86Z02*ENSMUSG0000000873066
Hipk3 / Q9ERH7 / Homeodomain-interacting protein kinase 3 / Q9H422*ENSMUSG0000002717752
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042419
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289717
Dyrk1b / Q9Z188 / Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Q9Y463*ENSMUSG0000000240915
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034513
Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*ENSMUSG0000002863013
Dyrk3 / Q922Y0 / Dual specificity tyrosine-phosphorylation-regulated kinase 3 / O43781*ENSMUSG0000001652612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0007224 smoothened signaling pathway IGI
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0030514 negative regulation of BMP signaling pathway ISO
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
 biological_processGO:0043388 positive regulation of DNA binding IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046330 positive regulation of JNK cascade ISS
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0050882 voluntary musculoskeletal movement IMP
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060235 lens induction in camera-type eye IMP
 biological_processGO:0060395 SMAD protein signal transduction ISO
 biological_processGO:0061072 iris morphogenesis IMP
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046332 SMAD binding ISO
 molecular_functionGO:0046790 virion binding ISS


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk2tm1Afus/Hipk2tm1Afus
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2+
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001095 enlarged trigeminal ganglion "increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve" [J:17131]
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Allelic Composition: Foxo3Gt(XAO26)Byg/Foxo3Gt(XAO26)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Hipk2tm1Afus/Hipk2tm1Afus
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pparatm1Gonz/Pparatm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2+
Genetic Background: involves: C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Hipk2tm1Afus/Hipk2tm1Afus
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0006102 reduced tegmentum "reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Hipk2tm1Afus/Hipk2tm1Afus
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009750 impaired behavioral response to addictive substance "decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011448 decreased dopaminergic neuron number "fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter" [MGI:smb]
Show

Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0020543 decreased substantia nigra size "decreased size of the substantia nigra" [MGI:smb]
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Allelic Composition: Hipk2tm1Ejh/Hipk2tm1Ejh
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000028211 Q9QXE4 / Trp53inp1 / transformation related protein 53 inducible nuclear protein 1 / Q96A56* / TP53INP1* / tumor protein p53 inducible nuclear protein 1*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction
 ENSMUSG00000032171 Pin1 / Q9QUR7 / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex
 ENSMUSG00000074997 Pin1rt1 / PIN1* / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*  / complex






 

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