ENSMUSG00000016526


Mus musculus

Features
Gene ID: ENSMUSG00000016526
  
Biological name :Dyrk3
  
Synonyms : Dual specificity tyrosine-phosphorylation-regulated kinase 3 / Dyrk3 / Q922Y0
  
Possible biological names infered from orthology : O43781
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 131127455
Gene end: 131138340
  
Corresponding Affymetrix probe sets: 10357590 (MoGene1.0st)   1424229_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140050
Ensembl peptide - ENSMUSP00000016670
NCBI entrez gene - 226419     See in Manteia.
MGI - MGI:1330300
RefSeq - NM_145508
RefSeq - XM_006529427
RefSeq Peptide - NP_663483
swissprot - A0A087WQ56
swissprot - Q922Y0
Ensembl - ENSMUSG00000016526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DYRK3ENSDARG00000070600Danio rerio
 DYRK3ENSGALG00000000863Gallus gallus
 DYRK3ENSG00000143479Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*ENSMUSG0000002863059
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034539
Dyrk1b / Q9Z188 / Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Q9Y463*ENSMUSG0000000240927
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289726
Hipk1 / O88904 / Homeodomain-interacting protein kinase 1 / Q86Z02*ENSMUSG0000000873025
Hipk3 / Q9ERH7 / Homeodomain-interacting protein kinase 3 / Q9H422*ENSMUSG0000002717725
Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*ENSMUSG0000006143624
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0035617 stress granule disassembly IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0080135 regulation of cellular response to stress IEA
 biological_processGO:1903432 regulation of TORC1 signaling IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gtf2iGt(RRI105)Byg/Gtf2iGt(RRI105)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Dyrk3tm1Dowo/Dyrk3tm1Dowo,Eportm2Jni/Eportm2Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gtf2iGt(RRI105)Byg/Gtf2iGt(RRI105)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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