ENSMUSG00000027177


Mus musculus

Features
Gene ID: ENSMUSG00000027177
  
Biological name :Hipk3
  
Synonyms : Hipk3 / Homeodomain-interacting protein kinase 3 / Q9ERH7
  
Possible biological names infered from orthology : Q9H422
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E2
Gene start: 104426481
Gene end: 104494446
  
Corresponding Affymetrix probe sets: 10485562 (MoGene1.0st)   1419191_at (Mouse Genome 430 2.0 Array)   1426819_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106754
Ensembl peptide - ENSMUSP00000028600
Ensembl peptide - ENSMUSP00000106753
NCBI entrez gene - 15259     See in Manteia.
MGI - MGI:1314882
RefSeq - NM_001145824
RefSeq - NM_010434
RefSeq Peptide - NP_001139296
RefSeq Peptide - NP_034564
swissprot - A2AQH3
swissprot - Q9ERH7
Ensembl - ENSMUSG00000027177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hipk3aENSDARG00000062469Danio rerio
 hipk3bENSDARG00000062082Danio rerio
 HIPK3ENSGALG00000011695Gallus gallus
 HIPK3ENSG00000110422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*ENSMUSG0000006143652
Hipk1 / O88904 / Homeodomain-interacting protein kinase 1 / Q86Z02*ENSMUSG0000000873049
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042419
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289716
Dyrk1b / Q9Z188 / Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Q9Y463*ENSMUSG0000000240914
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034513
Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*ENSMUSG0000002863013
Dyrk3 / Q922Y0 / Dual specificity tyrosine-phosphorylation-regulated kinase 3 / O43781*ENSMUSG0000001652612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0009299 mRNA transcription ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0043508 negative regulation of JUN kinase activity IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0016605 PML body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

 MP:0011820 decreased pancreatic beta cell proliferation "reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Trpc1tm1Lbi/Trpc1tm1Lbi,Trpc4tm1Bni/Trpc4tm1Bni
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr