ENSMUSG00000028630


Mus musculus

Features
Gene ID: ENSMUSG00000028630
  
Biological name :Dyrk2
  
Synonyms : Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Dyrk2 / Q5U4C9
  
Possible biological names infered from orthology : Q92630
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 118855603
Gene end: 118870209
  
Corresponding Affymetrix probe sets: 10372745 (MoGene1.0st)   1428637_at (Mouse Genome 430 2.0 Array)   1436918_at (Mouse Genome 430 2.0 Array)   1456502_at (Mouse Genome 430 2.0 Array)   1457667_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004281
NCBI entrez gene - 69181     See in Manteia.
MGI - MGI:1330301
RefSeq - XM_011243552
RefSeq - NM_001014390
RefSeq - XM_006514046
RefSeq Peptide - NP_001014412
swissprot - Q5U4C9
Ensembl - ENSMUSG00000028630
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dyrk2ENSDARG00000094646Danio rerio
 DYRK2ENSGALG00000009901Gallus gallus
 DYRK2ENSG00000127334Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dyrk3 / Q922Y0 / Dual specificity tyrosine-phosphorylation-regulated kinase 3 / O43781*ENSMUSG0000001652658
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034541
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289727
Dyrk1b / Q9Z188 / Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Q9Y463*ENSMUSG0000000240927
Hipk3 / Q9ERH7 / Homeodomain-interacting protein kinase 3 / Q9H422*ENSMUSG0000002717726
Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*ENSMUSG0000006143625
Hipk1 / O88904 / Homeodomain-interacting protein kinase 1 / Q86Z02*ENSMUSG0000000873025
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IEA
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction
 ENSMUSG00000034218 Atm / Q62388 / Serine-protein kinase ATM / Q13315* / ATM serine/threonine kinase*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr