ENSG00000127334


Homo sapiens

Features
Gene ID: ENSG00000127334
  
Biological name :DYRK2
  
Synonyms : dual specificity tyrosine phosphorylation regulated kinase 2 / DYRK2 / Q92630
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q15
Gene start: 67648338
Gene end: 67665406
  
Corresponding Affymetrix probe sets: 202968_s_at (Human Genome U133 Plus 2.0 Array)   202969_at (Human Genome U133 Plus 2.0 Array)   202970_at (Human Genome U133 Plus 2.0 Array)   202971_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324733
Ensembl peptide - ENSP00000377186
Ensembl peptide - ENSP00000440839
Ensembl peptide - ENSP00000443314
Ensembl peptide - ENSP00000342105
NCBI entrez gene - 8445     See in Manteia.
OMIM - 603496
RefSeq - XM_017020032
RefSeq - NM_003583
RefSeq - NM_006482
RefSeq Peptide - NP_003574
RefSeq Peptide - NP_006473
swissprot - Q92630
swissprot - A0A0A0MR56
swissprot - F5GXG1
swissprot - F5H5L5
Ensembl - ENSG00000127334
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dyrk2ENSDARG00000094646Danio rerio
 DYRK2ENSGALG00000009901Gallus gallus
 Dyrk2ENSMUSG00000028630Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DYRK3 / O43781 / dual specificity tyrosine phosphorylation regulated kinase 3ENSG0000014347958
DYRK4 / Q9NR20 / dual specificity tyrosine phosphorylation regulated kinase 4ENSG0000001021939
DYRK1A / Q13627 / dual specificity tyrosine phosphorylation regulated kinase 1AENSG0000015754028
DYRK1B / Q9Y463 / dual specificity tyrosine phosphorylation regulated kinase 1BENSG0000010520428
HIPK3 / Q9H422 / homeodomain interacting protein kinase 3ENSG0000011042226
HIPK1 / Q86Z02 / homeodomain interacting protein kinase 1ENSG0000016334926
HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2ENSG0000006439326
HIPK4 / Q8NE63 / homeodomain interacting protein kinase 4ENSG0000016039620
AC005832.4ENSG000002729216


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEP
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030145 manganese ion binding IDA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction






 

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