ENSG00000163349


Homo sapiens

Features
Gene ID: ENSG00000163349
  
Biological name :HIPK1
  
Synonyms : HIPK1 / homeodomain interacting protein kinase 1 / Q86Z02
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.2
Gene start: 113929192
Gene end: 113977869
  
Corresponding Affymetrix probe sets: 1552515_at (Human Genome U133 Plus 2.0 Array)   1552516_a_at (Human Genome U133 Plus 2.0 Array)   212291_at (Human Genome U133 Plus 2.0 Array)   212293_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407442
Ensembl peptide - ENSP00000358574
Ensembl peptide - ENSP00000422322
Ensembl peptide - ENSP00000486090
Ensembl peptide - ENSP00000426695
Ensembl peptide - ENSP00000340956
Ensembl peptide - ENSP00000355191
Ensembl peptide - ENSP00000358566
Ensembl peptide - ENSP00000358568
Ensembl peptide - ENSP00000358571
Ensembl peptide - ENSP00000358572
NCBI entrez gene - 204851     See in Manteia.
OMIM - 608003
RefSeq - XM_017000605
RefSeq - NM_152696
RefSeq - NM_181358
RefSeq - NM_198268
RefSeq - NM_198269
RefSeq - XM_005270609
RefSeq - XM_005270610
RefSeq - XM_005270611
RefSeq - XM_005270612
RefSeq - XM_005270613
RefSeq - XM_006710443
RefSeq - XM_011540977
RefSeq Peptide - NP_938010
RefSeq Peptide - NP_689909
RefSeq Peptide - NP_852003
RefSeq Peptide - NP_938009
swissprot - D6RF28
swissprot - Q86Z02
swissprot - A0A024R0H9
swissprot - Q5SQL3
swissprot - D6RC95
swissprot - H3BLW0
swissprot - J3KP92
Ensembl - ENSG00000163349
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hipk1aENSDARG00000063594Danio rerio
 si:ch211-160o17.4ENSDARG00000077095Danio rerio
 HIPK1ENSGALG00000001939Gallus gallus
 Hipk1ENSMUSG00000008730Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2ENSG0000006439365
HIPK3 / Q9H422 / homeodomain interacting protein kinase 3ENSG0000011042249
HIPK4 / Q8NE63 / homeodomain interacting protein kinase 4ENSG0000016039618
DYRK1A / Q13627 / dual specificity tyrosine phosphorylation regulated kinase 1AENSG0000015754016
DYRK1B / Q9Y463 / dual specificity tyrosine phosphorylation regulated kinase 1BENSG0000010520415
DYRK4 / Q9NR20 / dual specificity tyrosine phosphorylation regulated kinase 4ENSG0000001021913
DYRK2 / Q92630 / dual specificity tyrosine phosphorylation regulated kinase 2ENSG0000012733413
DYRK3 / O43781 / dual specificity tyrosine phosphorylation regulated kinase 3ENSG0000014347912
AC005832.4ENSG000002729212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0034333 adherens junction assembly IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IEA
 biological_processGO:0060216 definitive hemopoiesis ISS
 biological_processGO:0060235 lens induction in camera-type eye IEA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:0072577 endothelial cell apoptotic process IDA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Physiological factors
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000183072 NKX2-5 / P52952 / NK2 homeobox 5  / complex
 ENSG00000136574 GATA4 / P43694 / GATA binding protein 4  / complex






 

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