ENSMUSG00000008730


Mus musculus

Features
Gene ID: ENSMUSG00000008730
  
Biological name :Hipk1
  
Synonyms : Hipk1 / Homeodomain-interacting protein kinase 1 / O88904
  
Possible biological names infered from orthology : Q86Z02
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.2
Gene start: 103739815
Gene end: 103791563
  
Corresponding Affymetrix probe sets: 10500813 (MoGene1.0st)   1421298_a_at (Mouse Genome 430 2.0 Array)   1424540_at (Mouse Genome 430 2.0 Array)   1425988_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029438
Ensembl peptide - ENSMUSP00000102458
Ensembl peptide - ENSMUSP00000113998
Ensembl peptide - ENSMUSP00000120396
NCBI entrez gene - 15257     See in Manteia.
MGI - MGI:1314873
RefSeq - XM_011240024
RefSeq - NM_001301304
RefSeq - NM_001301306
RefSeq - NM_010432
RefSeq Peptide - NP_001288233
RefSeq Peptide - NP_001288235
RefSeq Peptide - NP_034562
swissprot - O88904
swissprot - A0A0R4J1V6
Ensembl - ENSMUSG00000008730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hipk1aENSDARG00000063594Danio rerio
 si:ch211-160o17.4ENSDARG00000077095Danio rerio
 HIPK1ENSGALG00000001939Gallus gallus
 HIPK1ENSG00000163349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*ENSMUSG0000006143665
Hipk3 / Q9ERH7 / Homeodomain-interacting protein kinase 3 / Q9H422*ENSMUSG0000002717749
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042418
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289716
Dyrk1b / Q9Z188 / Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Q9Y463*ENSMUSG0000000240915
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034513
Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*ENSMUSG0000002863013
Dyrk3 / Q922Y0 / Dual specificity tyrosine-phosphorylation-regulated kinase 3 / O43781*ENSMUSG0000001652612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007224 smoothened signaling pathway IGI
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0009952 anterior/posterior pattern specification IGI
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway ISO
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0034333 adherens junction assembly IMP
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
 biological_processGO:0043388 positive regulation of DNA binding ISS
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060235 lens induction in camera-type eye IMP
 biological_processGO:0061072 iris morphogenesis IMP
 biological_processGO:0072577 endothelial cell apoptotic process ISO
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2+
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko,Trp53tm2Mok/Trp53+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2+
Genetic Background: involves: C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Chgatm1Skmt/Chga+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hipk1tm1Hko/Hipk1tm1Hko,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a9tm1.1Bois/Slc6a9tm1.1Bois,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hipk1tm1Hko/Hipk1+,Hipk2tm1Hko/Hipk2tm1Hko
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction






 

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