ENSMUSG00000002409


Mus musculus

Features
Gene ID: ENSMUSG00000002409
  
Biological name :Dyrk1b
  
Synonyms : Dual specificity tyrosine-phosphorylation-regulated kinase 1B / Dyrk1b / Q9Z188
  
Possible biological names infered from orthology : Q9Y463
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 28179469
Gene end: 28187294
  
Corresponding Affymetrix probe sets: 10551469 (MoGene1.0st)   1422254_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000083064
Ensembl peptide - ENSMUSP00000133431
Ensembl peptide - ENSMUSP00000133719
NCBI entrez gene - 13549     See in Manteia.
MGI - MGI:1330302
RefSeq - XM_006539528
RefSeq - NM_001037957
RefSeq - NM_001271370
RefSeq - NM_010092
RefSeq - XM_006539526
RefSeq - XM_006539527
RefSeq Peptide - NP_001033046
RefSeq Peptide - NP_001258299
RefSeq Peptide - NP_034222
swissprot - Q9Z188
Ensembl - ENSMUSG00000002409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dyrk1bENSDARG00000070187Danio rerio
 DYRK1BENSG00000105204Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dyrk1a / Q61214 / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transcript variant 3, mRNA. / Q13627* / dual specificity tyrosine phosphorylation ...ENSMUSG0000002289761
Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*ENSMUSG0000006143627
Hipk1 / O88904 / Homeodomain-interacting protein kinase 1 / Q86Z02*ENSMUSG0000000873026
Hipk3 / Q9ERH7 / Homeodomain-interacting protein kinase 3 / Q9H422*ENSMUSG0000002717725
Dyrk2 / Q5U4C9 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q92630*ENSMUSG0000002863024
Dyrk4 / Q8BI55 / Dual specificity tyrosine-phosphorylation-regulated kinase 4 / Q9NR20*ENSMUSG0000003034523
Dyrk3 / Q922Y0 / Dual specificity tyrosine-phosphorylation-regulated kinase 3 / O43781*ENSMUSG0000001652623
Hipk4 / Q3V016 / Homeodomain-interacting protein kinase 4 / Q8NE63*ENSMUSG0000004042419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033565  Dual specificity tyrosine-phosphorylation-regulated kinase 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0007520 myoblast fusion IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0060612 adipose tissue development IEA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0012361 decreased large unstained cell number "decreased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts" [MPD:Molly, PMID:10388493]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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