ENSG00000105204


Homo sapiens

Features
Gene ID: ENSG00000105204
  
Biological name :DYRK1B
  
Synonyms : dual specificity tyrosine phosphorylation regulated kinase 1B / DYRK1B / Q9Y463
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 39825350
Gene end: 39834201
  
Corresponding Affymetrix probe sets: 204954_s_at (Human Genome U133 Plus 2.0 Array)   217270_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403182
Ensembl peptide - ENSP00000469863
Ensembl peptide - ENSP00000472941
Ensembl peptide - ENSP00000472861
Ensembl peptide - ENSP00000471609
Ensembl peptide - ENSP00000221803
Ensembl peptide - ENSP00000312789
NCBI entrez gene - 9149     See in Manteia.
OMIM - 604556
RefSeq - XM_005259398
RefSeq - NM_004714
RefSeq - NM_006483
RefSeq - NM_006484
RefSeq Peptide - NP_006475
RefSeq Peptide - NP_004705
RefSeq Peptide - NP_006474
swissprot - A0A024R0J6
swissprot - A0A024R0I0
swissprot - M0R2X3
swissprot - M0R131
swissprot - Q9Y463
swissprot - A0A024R0M8
Ensembl - ENSG00000105204
  
Related genetic diseases (OMIM): 615812 - Abdominal obesity-metabolic syndrome 3, 615812
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dyrk1bENSDARG00000070187Danio rerio
 Dyrk1bENSMUSG00000002409Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DYRK1A / Q13627 / dual specificity tyrosine phosphorylation regulated kinase 1AENSG0000015754065
HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2ENSG0000006439329
HIPK1 / Q86Z02 / homeodomain interacting protein kinase 1ENSG0000016334928
DYRK2 / Q92630 / dual specificity tyrosine phosphorylation regulated kinase 2ENSG0000012733427
HIPK3 / Q9H422 / homeodomain interacting protein kinase 3ENSG0000011042227
DYRK3 / O43781 / dual specificity tyrosine phosphorylation regulated kinase 3ENSG0000014347925
DYRK4 / Q9NR20 / dual specificity tyrosine phosphorylation regulated kinase 4ENSG0000001021925
HIPK4 / Q8NE63 / homeodomain interacting protein kinase 4ENSG0000016039622
AC005832.4ENSG000002729215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033565  Dual specificity tyrosine-phosphorylation-regulated kinase 1B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007520 myoblast fusion IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0060612 adipose tissue development IMP
 cellular_componentGO:0005634 nucleus TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000822 Hypertension "High blood pressure." [HPO:curators]
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 HP:0001297 Stroke 
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 HP:0001956 Truncal obesity "Obesity located preferentially in the trunk of the body as opposed to the extremities." [HPO:curators]
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 HP:0003124 Hypercholesterolemia 
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 HP:0012743 Abdominal obesity "Excessive fat around the stomach and abdomen." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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