ENSG00000064393


Homo sapiens

Features
Gene ID: ENSG00000064393
  
Biological name :HIPK2
  
Synonyms : HIPK2 / homeodomain interacting protein kinase 2 / Q9H2X6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q34
Gene start: 139561570
Gene end: 139777778
  
Corresponding Affymetrix probe sets: 213763_at (Human Genome U133 Plus 2.0 Array)   219028_at (Human Genome U133 Plus 2.0 Array)   224016_at (Human Genome U133 Plus 2.0 Array)   224065_at (Human Genome U133 Plus 2.0 Array)   224066_s_at (Human Genome U133 Plus 2.0 Array)   225097_at (Human Genome U133 Plus 2.0 Array)   225115_at (Human Genome U133 Plus 2.0 Array)   225116_at (Human Genome U133 Plus 2.0 Array)   225368_at (Human Genome U133 Plus 2.0 Array)   240294_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000343108
Ensembl peptide - ENSP00000385571
Ensembl peptide - ENSP00000413724
NCBI entrez gene - 28996     See in Manteia.
OMIM - 606868
RefSeq - XM_017012069
RefSeq - NM_001113239
RefSeq - NM_022740
RefSeq - XM_011516078
RefSeq - XM_011516079
RefSeq - XM_011516080
RefSeq - XM_011516081
RefSeq - XM_006715935
RefSeq - XM_011516077
RefSeq Peptide - NP_001106710
RefSeq Peptide - NP_073577
swissprot - Q9H2X6
swissprot - H7BXX9
Ensembl - ENSG00000064393
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIPK2ENSGALG00000012792Gallus gallus
 Hipk2ENSMUSG00000061436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIPK1 / Q86Z02 / homeodomain interacting protein kinase 1ENSG0000016334965
HIPK3 / Q9H422 / homeodomain interacting protein kinase 3ENSG0000011042252
HIPK4 / Q8NE63 / homeodomain interacting protein kinase 4ENSG0000016039618
DYRK1A / Q13627 / dual specificity tyrosine phosphorylation regulated kinase 1AENSG0000015754017
DYRK1B / Q9Y463 / dual specificity tyrosine phosphorylation regulated kinase 1BENSG0000010520415
DYRK2 / Q92630 / dual specificity tyrosine phosphorylation regulated kinase 2ENSG0000012733413
DYRK4 / Q9NR20 / dual specificity tyrosine phosphorylation regulated kinase 4ENSG0000001021913
DYRK3 / O43781 / dual specificity tyrosine phosphorylation regulated kinase 3ENSG0000014347912
AC005832.4ENSG000002729212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001654 eye development ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0018107 peptidyl-threonine phosphorylation ISS
 biological_processGO:0019048 modulation by virus of host morphology or physiology NAS
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030218 erythrocyte differentiation ISS
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0030514 negative regulation of BMP signaling pathway IMP
 biological_processGO:0030578 PML body organization TAS
 biological_processGO:0032092 positive regulation of protein binding ISS
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0051726 regulation of cell cycle TAS
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IEA
 biological_processGO:0060235 lens induction in camera-type eye IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:0071456 cellular response to hypoxia TAS
 biological_processGO:0097193 intrinsic apoptotic signaling pathway NAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IMP
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016604 nuclear body TAS
 cellular_componentGO:0016605 PML body IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding ISS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0046790 virion binding IPI


Pathways (from Reactome)
Pathway description
YAP1- and WWTR1 (TAZ)-stimulated gene expression
SUMOylation of transcription cofactors
Physiological factors
Regulation of TP53 Activity through Phosphorylation
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000183072 NKX2-5 / P52952 / NK2 homeobox 5  / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / complex / reaction
 ENSG00000127445 PIN1 / Q13526 / peptidylprolyl cis/trans isomerase, NIMA-interacting 1  / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000164938 Q96A56 / TP53INP1 / tumor protein p53 inducible nuclear protein 1  / reaction / complex
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / reaction
 ENSG00000169057 MECP2 / P51608 / methyl-CpG binding protein 2  / reaction
 ENSG00000136574 GATA4 / P43694 / GATA binding protein 4  / complex






 

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