ENSGALG00000012792


Gallus gallus

Features
Gene ID: ENSGALG00000012792
  
Biological name :HIPK2
  
Synonyms : HIPK2 / homeodomain interacting protein kinase 2
  
Possible biological names infered from orthology : Q9H2X6 / Q9QZR5
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 56075644
Gene end: 56198466
  
Corresponding Affymetrix probe sets: Gga.10876.1.A1_at (Chicken Array)   Gga.10876.1.S1_s_at (Chicken Array)   Gga.12888.1.S1_at (Chicken Array)   Gga.3318.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020844
NCBI entrez gene - 374138     See in Manteia.
RefSeq - XM_004937847
RefSeq - XM_004937848
RefSeq - XM_004937849
RefSeq - XM_015287609
RefSeq - XM_416335
RefSeq - XM_003640420
swissprot - F1P4G3
Ensembl - ENSGALG00000012792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HIPK2ENSG00000064393Homo sapiens
 Hipk2ENSMUSG00000061436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HIPK1 / homeodomain interacting protein kinase 1 / O88904* / Q86Z02*ENSGALG0000000193966
HIPK3 / homeodomain-interacting protein kinase 3 / Q9ERH7* / Q9H422*ENSGALG0000001169552
DYRK1A / dual specificity tyrosine-phosphorylation-regulated kinase 1A / Q13627* / Q61214* / Mus musculus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a (Dyrk1a), transc...ENSGALG0000001605316
DYRK3 / dual specificity tyrosine phosphorylation regulated kinase 3 / O43781* / Q922Y0*ENSGALG0000000086312
DYRK2 / Q5ZIU3 / Dual specificity tyrosine-phosphorylation-regulated kinase 2 / Q5U4C9* / Q92630*ENSGALG0000000990112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0007628 adult walking behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009952 anterior/posterior pattern specification IEA
 biological_processGO:0010842 retina layer formation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IEA
 biological_processGO:0050882 voluntary musculoskeletal movement IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IEA
 biological_processGO:0060235 lens induction in camera-type eye IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0061072 iris morphogenesis IEA
 biological_processGO:2000059 negative regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0046332 SMAD binding IEA
 molecular_functionGO:0046790 virion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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