ENSG00000143479


Homo sapiens

Features
Gene ID: ENSG00000143479
  
Biological name :DYRK3
  
Synonyms : dual specificity tyrosine phosphorylation regulated kinase 3 / DYRK3 / O43781
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 206635536
Gene end: 206684419
  
Corresponding Affymetrix probe sets: 1560785_at (Human Genome U133 Plus 2.0 Array)   210151_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356073
Ensembl peptide - ENSP00000356075
Ensembl peptide - ENSP00000356076
Ensembl peptide - ENSP00000410187
NCBI entrez gene - 8444     See in Manteia.
OMIM - 603497
RefSeq - XM_005273315
RefSeq - NM_001004023
RefSeq - NM_003582
RefSeq Peptide - NP_003573
RefSeq Peptide - NP_001004023
swissprot - O43781
swissprot - Q5SY34
Ensembl - ENSG00000143479
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DYRK3ENSDARG00000070600Danio rerio
 DYRK3ENSGALG00000000863Gallus gallus
 Dyrk3ENSMUSG00000016526Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DYRK2 / Q92630 / dual specificity tyrosine phosphorylation regulated kinase 2ENSG0000012733459
DYRK4 / Q9NR20 / dual specificity tyrosine phosphorylation regulated kinase 4ENSG0000001021940
DYRK1A / Q13627 / dual specificity tyrosine phosphorylation regulated kinase 1AENSG0000015754027
DYRK1B / Q9Y463 / dual specificity tyrosine phosphorylation regulated kinase 1BENSG0000010520426
HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2ENSG0000006439325
HIPK1 / Q86Z02 / homeodomain interacting protein kinase 1ENSG0000016334924
HIPK3 / Q9H422 / homeodomain interacting protein kinase 3ENSG0000011042224
HIPK4 / Q8NE63 / homeodomain interacting protein kinase 4ENSG0000016039620
AC005832.4ENSG000002729215


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030218 erythrocyte differentiation IDA
 biological_processGO:0035617 stress granule disassembly IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator IEA
 biological_processGO:0080135 regulation of cellular response to stress IMP
 biological_processGO:1903432 regulation of TORC1 signaling IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0010494 cytoplasmic stress granule IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity IMP
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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