| MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0000771 | abnormal brain size | "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0000832 | abnormal thalamus morphology | "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0000859 | abnormal somatosensory cortex morphology | "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0001417 | decreased exploration in new environment | "less amount of time spent investigating a new location" [J:79870] |
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr
Genetic Background: involves: C57BL/6J * C57BL/6JJcl
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| MP:0001698 | reduced embryo size | "smaller proportions of embryo compared to littermates" [J:61790] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0002175 | low brain weight | "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0002834 | decreased heart weight | "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0002892 | reduced size of superior colliculus | "decreased size of the paired superior eminence of the mesencephalic tectum" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0003861 | abnormal nervous system development | "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0004179 | transmission ratio distortion | "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr
Genetic Background: involves: C57BL/6J * C57BL/6JJcl
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| MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0006105 | reduced tectum size | "reduced size of the rostral part of the midbrain roof" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65410] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0006413 | increased T cell apoptosis | "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0008209 | decreased pre-B cell number | "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0008211 | decreased mature B cell number | "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J
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| MP:0009454 | impaired contextual conditioning | "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr
Genetic Background: involves: C57BL/6J * C57BL/6JJcl
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| MP:0009969 | abnormal cerebral cortex pyramidal cell morphology | "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Kdelr1em1Btlr/Kdelr1em1Btlr
Genetic Background: involves: C57BL/6J * C57BL/6JJcl
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| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0012089 | decreased midbrain size | "size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0012263 | decreased hindbrain size | "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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| MP:0020083 | decreased hippocampus volume | "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV] |
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip,Lect2tm1Ymg/Lect2tm1Ymg,Tg(Ttr-cre/Esr1*)1Vco/0
Genetic Background: B6.Cg-Lect2tm1Ymg Apctm2.1Cip Tg(Ttr-cre/Esr1*)1Vco
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| MP:0020568 | abnormal premotor cortex morphology | "any structural anomaly of the part of the motor cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord; the premotor cortex influences movements of the face, neck and trunk, and upper and lower extremities" [UBERON:0016634, url:http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=2331] |
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Allelic Composition: Ireb2tm1.2Mwh/Ireb2tm1.2Mwh
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * SJL
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