MP:0000358 | abnormal cell content/ morphology | "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000490 | abnormal crypts of Lieberkuhn morphology | "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0001559 | hyperglycemia | "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002044 | colonic adenoma | "benign tumors of the large intestine" [J:38772] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0003304 | large intestinal inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0005455 | increased weight gain | "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0006319 | abnormal epididymal fat pad | "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008537 | increased susceptibility to induced colitis | "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008902 | abnormal renal fat pad morphology | "any structural anomaly of the encapsulated adipose tissue associated with the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0010955 | abnormal respiratory electron transport chain | "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0010959 | abnormal oxidative phosphorylation | "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0011628 | increased mitochondria number | "greater than normal number of the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0014046 | abnormal mitophagy | "any anomaly in the autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions" [MGI:Anna, PMID:22743996] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0014142 | increased body fat mass | "increased physical bulk or volume of fat in the whole body" [MGI:csmith] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0020089 | increased susceptibility to diet-induced non-insulin dependent diabetes | "increased likelihood to develop diet-induced non-insulin-dependent diabetes" [GOC:NV] |
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst Genetic Background: involves: 129X1/SvJ * C57BL/6
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