| MP:0000060 | delayed bone ossification | "late onset of the formation of bone" [J:40203] |
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0000074 | abnormal neurocranium morphology | "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
|
| MP:0000149 | abnormal scapula morphology | "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0000150 | abnormal rib morphology | "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0000157 | abnormal sternum morphology | "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0000165 | abnormal hypertrophic chondrocyte zone | "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000166 | abnormal chondrocyte morphology | "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203] |
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv
|
| MP:0000218 | increased WBC count | "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0000229 | abnormal megakaryocyte differentiation | "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
|
| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
|
| MP:0000245 | abnormal erythropoiesis | "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
|
| MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
|
| MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0000455 | abnormal maxilla morphology | "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0000458 | abnormal mandible morphology | "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
|
| MP:0000547 | short limbs | "reduced average length of the extremities" [MGI:CLS, J:61509] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000596 | abnormal liver development | "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
|
| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
Show
Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
Show
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
|
| MP:0000703 | abnormal thymus morphology | "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
|
| MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
|
| MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
Show
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
|
| MP:0000969 | abnormal nociceptor morphology | "anomalous structure of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
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| MP:0000972 | abnormal mechanoreceptor morphology | "anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:34172] |
Show
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
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| MP:0001302 | eyelids open at birth | "widely open eyes instead of closed at perinatal stage" [J:51966] |
Show
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
Show
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
Show
Allelic Composition: Zic1tm1Jaru/Zic1tm1Jaru
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0001606 | impaired hematopoiesis | "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
Show
Allelic Composition: Cln8mnd/Cln8mnd
Genetic Background: AK.B6(Cg)-Cln8mnd
Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified
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| MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
Show
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
Show
Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
Show
Allelic Composition: Cln8mnd/Cln8mnd
Genetic Background: AK.B6(Cg)-Cln8mnd
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Cln8mnd/Cln8mnd
Genetic Background: AK.B6(Cg)-Cln8mnd
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| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified
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| MP:0001917 | intraventricular hemorrhage | "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Cbfbtm1Tno/Cbfbtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
Show
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
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| MP:0002113 | abnormal skeleton development | "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0002114 | abnormal axial skeleton morphology | "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0002115 | abnormal skeleton extremities morphology | "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Cbfbtm1Tno/Cbfbtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0002145 | abnormal T lymphocyte development | "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7b+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen
Genetic Background: B6.Cg-Gt(ROSA)26Sortm2.1(CAG-EGFP,-DTA*G128D)Pjen/J
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| MP:0002398 | abnormal bone marrow cell morphology/development | "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0002408 | abnormal double-positive T cell | "anomalous development or number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0002414 | abnormal myeloblast morphology/development | "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0002417 | abnormal megakaryocyte morphology/development | "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0002445 | abnormal mononuclear leukocyte morphology/development | "anomalous structure, differentiation, or number of either of the mature lymphocytes or monocytes found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified
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| MP:0002450 | abnormal lymph organ development | "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002461 | increased circulating immunoglobulin concentration | "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002495 | increased IgA | "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002497 | increased IgE | "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv
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| MP:0002831 | absent Peyer s patches | "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003072 | abnormal metatarsal bone morphology | "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0003073 | abnormal metacarpal bone morphology | "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0003135 | increased erythrocyte precursors | "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0003396 | abnormal embryonic hematopoiesis | "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
" [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Tno/Cbfbtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0003419 | delayed endochondral bone ossification | "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0003420 | delayed intramembranous bone ossification | "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0003658 | abnormal capillaries | "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0003717 | pallor | "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
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| MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
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| MP:0003944 | abnormal T cell subpopulation ratio | "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0004134 | abnormal chest morphology | "malformation of the part of the body between the neck and the abdomen " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:59168] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004214 | abnormal long bone diaphysis morphology | "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0004339 | absent clavicle | "missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0004358 | bowed tibia | "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0004508 | abnormal shoulder bone morphology | "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0004809 | increased hematopoietic stem cell number | "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Lhc/Cbfbtm1Lhc,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
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| MP:0004810 | decreased hematopoietic stem cell number | "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0005010 | abnormal CD8+ T cell morphology/development | "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0005016 | decreased lymphocyte number | "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0005091 | increased double-positive T cell count | "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0005225 | abnormal vertebrae development | "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0005244 | hemopericardium | "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0] |
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Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0005298 | abnormal clavicle morphology | "malformation of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0005306 | abnormal phalanx morphology | "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cacna1atg-la/Cacna1atg-la
Genetic Background: B6.Cg-Os +/+ Cacna1atg-la/J
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cbfbtm2.1Ddg/Cbfbtm2.1Ddg,Mapttm2Arbr/?,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J
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| MP:0005435 | hemoperitoneum | "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293] |
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Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0006051 | brainstem hemorrhage | "bleeding into the brain stem" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0006054 | spinal hemorrhage | "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Cbfbtm1Tno/Cbfbtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
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| MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0008070 | absent T cells | "absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008074 | increased CD4-positive T cell number | "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm2.1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7b+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Zbtb7btm2Litt/Zbtb7btm1.2Litt,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0008076 | abnormal CD4-positive T cell differentiation | "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008077 | abnormal CD8-positive T cell number | "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008078 | increased CD8-positive T cell number | "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Cd4tm3.1Litt/Cd4tm3.1Litt,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008080 | abnormal CD8-positive T cell differentiation | "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008088 | abnormal T-helper 1 cell differentiation | "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008133 | decreased Peyer s patch number | "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008253 | absent megakaryocytes | "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Cbfbtm4Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0008271 | abnormal bone ossification | "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008273 | abnormal intramembranous bone ossification | "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0008395 | abnormal osteoblast differentiation | "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0008463 | abnormal peripheral lymph node morphology | "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tmem173tm1Gnb/Tmem173tm1Gnb
Genetic Background: involves: 129P2/OlaHsd
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| MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Itan/Cbfbtm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
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| MP:0008826 | abnormal splenic cell ratio | "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm2.1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0008827 | abnormal thymus cell ratio | "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"] |
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Allelic Composition: Cbfbtm2.1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0008974 | proportional dwarf | "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0009908 | protruding tongue | "the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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| MP:0010373 | myeloid hyperplasia | "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Snai2tm2Grid/Snai2tm2Grid
Genetic Background: involves: 129S1/Sv
Allelic Composition: Cbfbtm2.1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Cbfbtm1Spe/Cbfbtm2.1Spe
Genetic Background: involves: 129S4/SvJae
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
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Allelic Composition: Cbfbtm1Lhc/Cbfb+,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Alx1tm1Crm/Alx1tm1Crm,Alx4tm1Rwi/Alx4tm1Rwi
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd
Allelic Composition: Cbfbtm1Tno/Cbfbtm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
Allelic Composition: Cbfbtm1Ppl/Cbfb+
Genetic Background: either: (involves: 129/Sv * 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Allelic Composition: CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove/CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove
Genetic Background: FVB/N-CbfbTgTn(sb-cHS4,Tyr)2512E-2Ove
Allelic Composition: Cbfbtm5Ppl/Cbfbtm5Ppl
Genetic Background: Not Specified
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Cbfbtm3Ppl/Cbfb+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0011179 | decreased erythroblast number | "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
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| MP:0011712 | absent osteoblast differentiation | |
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Allelic Composition: Cbfbtm1Tok/Cbfbtm1Tok,Tg(Gata1-Cbfb)1Tok/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0014106 | delayed chondrocyte differentiation | "delay in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062] |
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Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)1Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1) or (involves: 129S4/SvJae * C57BL/6 * CD-1)
Allelic Composition: Cbfbtm1Spe/Cbfbtm1Spe,Tg(Tek-GFP/Cbfb)2Spe/0
Genetic Background: either: (involves: 129S4/SvJae * BALB/c * CD-1 * Swiss Webster) or (involves: 129S4/SvJae * C57BL/6 * CD-1 * Swiss Webster)
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