ENSMUSG00000060284


Mus musculus

Features
Gene ID: ENSMUSG00000060284
  
Biological name :Sp7
  
Synonyms : Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8VI67 / Sp7
  
Possible biological names infered from orthology : Q8TDD2 / Sp7 transcription factor
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 102356606
Gene end: 102367182
  
Corresponding Affymetrix probe sets: 10433003 (MoGene1.0st)   1418425_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077596
Ensembl peptide - ENSMUSP00000154859
NCBI entrez gene - 170574     See in Manteia.
MGI - MGI:2153568
RefSeq - XM_006520520
RefSeq - NM_001348205
RefSeq - NM_130458
RefSeq - XM_006520519
RefSeq Peptide - NP_001335134
RefSeq Peptide - NP_569725
swissprot - Q2KHK9
swissprot - Q5RM08
swissprot - Q8VI67
Ensembl - ENSMUSG00000060284
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp7ENSDARG00000019516Danio rerio
 SP7ENSG00000170374Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885936
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856234
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710930
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532330
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128029
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856029
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530427
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867824
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065321
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746520
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204018
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539717
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386316
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320916


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060218 hematopoietic stem cell differentiation IEA
 biological_processGO:2000738 positive regulation of stem cell differentiation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017151 DEAD/H-box RNA helicase binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Men1tm1Mmey/Men1+
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sp7tm1.1Rnis/Sp7tm1.1Rnis
Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp27a1tm1Elt/Cyp27a1tm1Elt,Cyp2r1tm1(KOMP)Vlcg/Cyp2r1tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6J * C57BL/6N * C57BL/6NTac

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL

 MP:0004337 clavicle hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008274 failure of bone ossification "failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Sp7tm1.1Rnis/Sp7tm1.1Rnis
Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

 MP:0008275 failure of endochondral bone ossification "failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Sp7tm1.1Rnis/Sp7tm1.1Rnis
Genetic Background: involves: C57BL * C57BL/6NCrlj * CBA/JNCrlj * DBA

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Col11a2-cre)1Ntsu/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * DBA/2

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL

Allelic Composition: Sp7tm1Rnis/Sp7tm1Rnis,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: C57BL * C57BL/6 * CBA/JNCrlj * SJL/J

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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