ENSMUSG00000037465


Mus musculus

Features
Gene ID: ENSMUSG00000037465
  
Biological name :Klf10
  
Synonyms : Klf10 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / O89091
  
Possible biological names infered from orthology : Kruppel like factor 10 / Q13118
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B3.1
Gene start: 38291463
Gene end: 38300706
  
Corresponding Affymetrix probe sets: 10428302 (MoGene1.0st)   1416029_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000073690
Ensembl peptide - ENSMUSP00000153975
Ensembl peptide - ENSMUSP00000154055
Ensembl peptide - ENSMUSP00000154669
Ensembl peptide - ENSMUSP00000154702
Ensembl peptide - ENSMUSP00000154265
NCBI entrez gene - 21847     See in Manteia.
MGI - MGI:1101353
RefSeq - XM_006520046
RefSeq - NM_001289471
RefSeq - NM_001357677
RefSeq - NM_013692
RefSeq Peptide - NP_001344606
RefSeq Peptide - NP_038720
RefSeq Peptide - NP_001276400
swissprot - O89091
swissprot - Q8C900
Ensembl - ENSMUSG00000037465
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLF10ENSGALG00000037913Gallus gallus
 KLF10ENSG00000155090Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065338
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128020
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710920
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867820
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532319
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204018
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028418
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320918
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856218
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539717
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885916
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530416
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386316
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856015


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0035019 somatic stem cell population maintenance IDA
 biological_processGO:0042752 regulation of circadian rhythm IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nrg1tm1Gne/Nrg1tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008156 decreased diameter of tibia "reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Nrg1tm1Gne/Nrg1tm1Gne
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0009580 increased keratinocyte apoptosis "increase in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010968 decreased compact bone area "reduction in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0030483 decreased osteocyte number "reduction in the number of mature osteoblasts that have become embedded in the bone matrix (osteoid) in small cavities called lacunae and that extend cytoplasmic (dendritic) processes away from the cell body toward other osteocytes and neighboring cells in small channels called canaliculi" [MGI:anna]
Show

Allelic Composition: Grin1tm1Rsp/Grin1tm1Rsp,Tg(Slc6a3-icre)9075Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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