ENSMUSG00000075304


Mus musculus

Features
Gene ID: ENSMUSG00000075304
  
Biological name :Sp5
  
Synonyms : Q9JHX2 / Sp5 / Transcription factor Sp5
  
Possible biological names infered from orthology : Q6BEB4 / Sp5 transcription factor
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: C2
Gene start: 70474923
Gene end: 70477729
  
Corresponding Affymetrix probe sets: 10472688 (MoGene1.0st)   1422914_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097620
NCBI entrez gene - 64406     See in Manteia.
MGI - MGI:1927715
RefSeq - NM_022435
RefSeq Peptide - NP_071880
swissprot - Q9JHX2
Ensembl - ENSMUSG00000075304
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp5aENSDARG00000076571Danio rerio
 sp5lENSDARG00000115868Danio rerio
 SP5ENSGALG00000034094Gallus gallus
 SP5ENSG00000204335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885936
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532336
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710934
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128034
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856234
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856031
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028429
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867829
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065322
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746519
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204018
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386317
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320917
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539716


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0036342 post-anal tail morphogenesis IGI
 biological_processGO:0060349 bone morphogenesis IGI
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox4tm2Cle/Sox4tm2Cle
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp5tm1Rbe/Sp5tm1Rbe,T/T+
Genetic Background: involves: 129P2/Ola * C57BL/6J

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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