ENSMUSG00000073209


Mus musculus

Features
Gene ID: ENSMUSG00000073209
  
Biological name :Klf14
  
Synonyms : Klf14 / Krueppel-like factor 14 / Q19A41
  
Possible biological names infered from orthology : Kruppel like factor 14
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 30956023
Gene end: 30959078
  
Corresponding Affymetrix probe sets: 10543772 (MoGene1.0st)   1457397_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099122
NCBI entrez gene - 619665     See in Manteia.
MGI - MGI:3577024
RefSeq - NM_001135093
RefSeq Peptide - NP_001128565
swissprot - Q19A41
Ensembl - ENSMUSG00000073209
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLF14ENSG00000266265Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539741
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204036
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386331
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065328
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746526
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885922
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532322
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856222
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128022
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028422
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710922
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867821
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530421
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856019


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:1902070 positive regulation of sphingolipid mediated signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003382 straub tail "condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ell2tm2.1Cmil/Ell2tm2.1Cmil
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Ilktm1Star/Ilktm1Star,Tg(Ckmm-cre)1Lrsn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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