ENSMUSG00000018678


Mus musculus

Features
Gene ID: ENSMUSG00000018678
  
Biological name :Sp2
  
Synonyms : Sp2 / Sp2 transcription factor
  
Possible biological names infered from orthology : Q02086
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 96953341
Gene end: 96982959
  
Corresponding Affymetrix probe sets: 10390308 (MoGene1.0st)   1426237_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051403
Ensembl peptide - ENSMUSP00000103249
Ensembl peptide - ENSMUSP00000103250
NCBI entrez gene - 78912     See in Manteia.
MGI - MGI:1926162
RefSeq - XM_006534521
RefSeq - NM_001080964
RefSeq - NM_030220
RefSeq - XM_006534518
RefSeq - XM_006534519
RefSeq - XM_006534520
RefSeq Peptide - NP_001074433
RefSeq Peptide - NP_084496
swissprot - Q8BNQ4
swissprot - Q8C5J0
Ensembl - ENSMUSG00000018678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp2ENSDARG00000076763Danio rerio
 SP2ENSGALG00000000233Gallus gallus
 SP2ENSG00000167182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532333
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710931
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128031
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885920
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530419
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856218
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065318
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028416
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746515
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856015
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204012
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320911
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539711
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386311


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030451  Transcription factor Sp2
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0035264 multicellular organism growth IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg
Genetic Background: involves: 129

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0008540 abnormal cerebrum morphology "any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sp2tm1.1Htg/Sp2tm1.1Htg,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Drd2tm1Ebo/Drd2tm1Ebo
Genetic Background: B6.129S2-Drd2tm1Ebo

 MP:0020083 decreased hippocampus volume "decrease from the average range of the hippocampus volume compared to normal" [GOC:NV]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0020394 decreased neuronal precursor proliferation "reduction in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:anna]
Show

Allelic Composition: Pkd1tm1.1Fqi/Pkd1tm1.1Fqi
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sp2tm1.1Htg/Sp2+,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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