ENSMUSG00000052040


Mus musculus

Features
Gene ID: ENSMUSG00000052040
  
Biological name :Klf13
  
Synonyms : Klf13 / Krueppel-like factor 13 / Q9JJZ6
  
Possible biological names infered from orthology : Kruppel like factor 13 / Q9Y2Y9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: C
Gene start: 63886351
Gene end: 63938915
  
Corresponding Affymetrix probe sets: 10564290 (MoGene1.0st)   1432543_a_at (Mouse Genome 430 2.0 Array)   1436316_at (Mouse Genome 430 2.0 Array)   1456030_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140381
Ensembl peptide - ENSMUSP00000067680
Ensembl peptide - ENSMUSP00000139049
NCBI entrez gene - 50794     See in Manteia.
MGI - MGI:1354948
RefSeq - NM_021366
RefSeq Peptide - NP_067341
swissprot - A0A087WQX4
swissprot - Q9JJZ6
swissprot - V9GX95
Ensembl - ENSMUSG00000052040
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klf13ENSDARG00000061368Danio rerio
 KLF13ENSGALG00000032748Gallus gallus
 KLF13ENSG00000169926Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320940
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539738
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386337
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065333
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746530
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710928
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532328
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028427
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885926
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856226
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128026
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530425
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867825
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856022


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0045647 negative regulation of erythrocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tcratm1Mom/Tcratm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkcqtm1Litt/Prkcqtm1Litt,Tcratm1Mom/Tcratm1Mom
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0009341 decreased splenocyte apoptosis "reduction in the number of spleen cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0010067 increased red blood cell distribution width "higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]
Show

Allelic Composition: Klf13tm1Coll/Klf13tm1Coll
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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