ENSMUSG00000038560


Mus musculus

Features
Gene ID: ENSMUSG00000038560
  
Biological name :Sp6
  
Synonyms : Q9ESX2 / Sp6 / trans-acting transcription factor 6
  
Possible biological names infered from orthology : Q3SY56 / Sp6 transcription factor
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 97013394
Gene end: 97024734
  
Corresponding Affymetrix probe sets: 10380719 (MoGene1.0st)   1427787_at (Mouse Genome 430 2.0 Array)   1437788_at (Mouse Genome 430 2.0 Array)   1442342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103248
Ensembl peptide - ENSMUSP00000039307
NCBI entrez gene - 83395     See in Manteia.
MGI - MGI:1932575
RefSeq - NM_031183
RefSeq - XM_006534531
RefSeq Peptide - NP_112460
swissprot - A2A708
swissprot - Q9ESX2
Ensembl - ENSMUSG00000038560
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp6ENSDARG00000099880Danio rerio
 SP6ENSG00000189120Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856240
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885938
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530433
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028433
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128031
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532330
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710929
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867824
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065322
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746519
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204017
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320916
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539715
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386315


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II ISS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0042481 regulation of odontogenesis IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0000387 disorganized inner root sheath cells "disordered enveloping layer of cells of the hair follicle; comprises the cuticle of the inner roots" [J:56777]
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Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0000564 syndactyly "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0000652 enlarged sebaceous gland "increased size of the sebum secreting glands of the hair shaft" [J:30249]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001274 curly vibrissae "whiskers twisted into coils or spirals" [J:47620]
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Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001282 short vibrissae "decreased length of the vibrissae" [J:30249]
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Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
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Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0002577 reduced enamel thickness "thin hard coating of the exposed portion of the tooth" [J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0002650 abnormal ameloblast morphology "malformation of the epithelial cells of the inner layer of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0002817 abnormal tooth mineralization "abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003404 absent enamel "absence of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:92017]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0003810 abnormal hair cuticle "anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0003815 nude "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0003930 abnormal tooth hard tissue morphology "defects in the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0004033 supernumerary teeth "occurrence of more than the usual number of teeth" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0005358 abnormal incisor morphology "structural defect of the long pointed teeth; most anterior and prominent in the jaw" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85574]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0006369 supernumerary incisors "more than a pair, top and/or bottom, of the long pointed teeth that are the most anterior and prominent in the jaw" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010685 abnormal hair follicle inner root sheath morphology "any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle s layer, Huxley s layer and the inner root sheath cuticle" [PMID:19211055]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0010747 abnormal enamel organ morphology "any structural anomaly of the circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0010773 supernumerary molars "increased number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0013129 abnormal tooth color "anomaly in the color and shading of the teeth, which normally present in shades of white" [MGI:Ahmad_Retha]
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Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030079 small incisors "reduced size of the set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030088 microdontia "abnormal reduction in the size of one or more teeth" [MGI:anna]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
Show

Allelic Composition: Il1r1tm1Imx/Il1r1tm1Imx,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030472 fused teeth "union of two separately developing tooth germs typically leading to one less tooth than normal in the affected arch" [HP:0011090, PMID:18167487]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030473 fused molars "union of two adjacent molar teeth in the maxilla and/or mandible" [MGI:anna]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030497 short tooth root "decreased length of the part of a tooth that is implanted in the gum; the root is located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
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Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

 MP:0030525 abnormal Hertwig epithelial root sheath morphology "any structural anomaly of the bilayered epithelial sheath formed from the fusion of the inner and outer enamel epithelia below the level of the cervical margin of the crown; in mammals, HERS is a transient structure and fragments to form the epithelial cell rests of Malassez; HERS cells appear to be involved in the initiation of the root formation process, in root elongation, and in stimulating both cementogenesis and root dentinogenesis" [https://en.wikipedia.org/wiki/Epithelial_root_sheath, PMID:19576204]
Show

Allelic Composition: Sp6tm1.1Ibmm/Sp6tm1.1Ibmm
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/c * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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