ENSMUSG00000001280


Mus musculus

Features
Gene ID: ENSMUSG00000001280
  
Biological name :Sp1
  
Synonyms : O89090 / Sp1 / Transcription factor Sp1
  
Possible biological names infered from orthology : P08047 / Sp1 transcription factor
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F3
Gene start: 102406143
Gene end: 102436404
  
Corresponding Affymetrix probe sets: 10427214 (MoGene1.0st)   1418180_at (Mouse Genome 430 2.0 Array)   1448994_at (Mouse Genome 430 2.0 Array)   1454852_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127445
Ensembl peptide - ENSMUSP00000130747
Ensembl peptide - ENSMUSP00000129638
Ensembl peptide - ENSMUSP00000127714
Ensembl peptide - ENSMUSP00000001326
Ensembl peptide - ENSMUSP00000126143
NCBI entrez gene - 20683     See in Manteia.
MGI - MGI:98372
RefSeq - XM_017316523
RefSeq - NM_013672
RefSeq Peptide - NP_038700
swissprot - G3X8Q0
swissprot - E9Q113
swissprot - E9Q2V3
swissprot - O89090
swissprot - E9Q0S7
Ensembl - ENSMUSG00000001280
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp1ENSDARG00000088347Danio rerio
 SP1ENSGALG00000035487Gallus gallus
 SP1ENSG00000185591Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532337
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710935
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867824
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885919
Sp8 / Q8BMJ8 / Transcription factor Sp8 / Q8IXZ3* / Sp8 transcription factor*ENSMUSG0000004856219
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530417
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028416
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856015
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065314
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746512
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204010
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539710
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG000000338639
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG000000732099


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR030449  Transcription factor Sp1
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IGI
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0001829 trophectodermal cell differentiation IGI
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001892 embryonic placenta development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030219 megakaryocyte differentiation IGI
 biological_processGO:0030324 lung development IGI
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043353 enucleate erythrocyte differentiation IGI
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048596 embryonic camera-type eye morphogenesis IGI
 biological_processGO:0048706 embryonic skeletal system development IGI
 biological_processGO:0060136 embryonic process involved in female pregnancy IGI
 biological_processGO:0060216 definitive hemopoiesis IGI
 biological_processGO:1904828 positive regulation of hydrogen sulfide biosynthetic process IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IPI
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0035326 enhancer binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0043425 bHLH transcription factor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070491 repressing transcription factor binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
RNA polymerase II transcribes snRNA genes
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sp1tm1Phi/Sp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sp1tm1Phi/Sp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008959 abnormal spongiotrophoblast cell morphology "any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Sp1tm1Phi/Sp1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010128 hypovolemia "an abnormally decreased amount of space occupied by blood in the vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011525 abnormal placenta intervillous maternal lacunae morphology "any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011527 disorganized placental labyrinth "derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012109 decreased trophoblast glycogen cell number "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
Show

Allelic Composition: Sp1tm1Phi/Sp1+,Sp3tm1Sus/Sp3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024563 Smad2 / Q62432 / Mothers against decapentaplegic homolog 2 / Q15796* / SMAD family member 2*  / reaction / complex
 ENSMUSG00000026565 P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*  / complex
 ENSMUSG00000024515 Smad4 / P97471 / Mothers against decapentaplegic homolog 4 / Q13485* / SMAD family member 4*  / reaction / complex
 ENSMUSG00000032402 Smad3 / Q8BUN5 / Mothers against decapentaplegic homolog 3 / P84022* / SMAD family member 3*  / complex / reaction
 ENSMUSG00000061079 O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*  / complex
 ENSMUSG00000008496 Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr