ENSMUSG00000008496


Mus musculus

Features
Gene ID: ENSMUSG00000008496
  
Biological name :Pou2f2
  
Synonyms : Pou2f2 / POU domain, class 2, transcription factor 2 / Q00196
  
Possible biological names infered from orthology : P09086 / POU class 2 homeobox 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25087344
Gene end: 25179726
  
Corresponding Affymetrix probe sets: 10560964 (MoGene1.0st)   1427713_x_at (Mouse Genome 430 2.0 Array)   1427725_a_at (Mouse Genome 430 2.0 Array)   1443885_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135326
Ensembl peptide - ENSMUSP00000096276
Ensembl peptide - ENSMUSP00000104051
Ensembl peptide - ENSMUSP00000104053
Ensembl peptide - ENSMUSP00000104054
Ensembl peptide - ENSMUSP00000104055
Ensembl peptide - ENSMUSP00000104056
Ensembl peptide - ENSMUSP00000118307
Ensembl peptide - ENSMUSP00000135075
NCBI entrez gene - 18987     See in Manteia.
MGI - MGI:101897
RefSeq - XM_011250457
RefSeq - XM_006539655
RefSeq - XM_006539656
RefSeq - XM_006539658
RefSeq - XM_006539659
RefSeq - XM_006539660
RefSeq - XM_006539661
RefSeq - XM_006539662
RefSeq - NM_001163554
RefSeq - NM_001163555
RefSeq - NM_001163556
RefSeq - NM_011138
RefSeq - XM_006539647
RefSeq - XM_006539648
RefSeq - XM_006539649
RefSeq - XM_006539650
RefSeq - XM_006539651
RefSeq - XM_006539652
RefSeq - XM_006539653
RefSeq - XM_006539654
RefSeq Peptide - NP_035268
RefSeq Peptide - NP_001157026
RefSeq Peptide - NP_001157027
RefSeq Peptide - NP_001157028
swissprot - Q00196
swissprot - H3BKB7
swissprot - F6X6U7
Ensembl - ENSMUSG00000008496
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou2f2aENSDARG00000036816Danio rerio
 pou2f2aENSDARG00000019658Danio rerio
 P09086ENSG00000028277Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656552
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201536
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551525
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513923
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685423
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012522
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440621
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484217
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834917
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168817
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449716
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR000972  Octamer-binding transcription factor
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002335 mature B cell differentiation IMP
 biological_processGO:0002380 immunoglobulin secretion involved in immune response IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048305 immunoglobulin secretion IMP
 biological_processGO:0048469 cell maturation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
RNA polymerase II transcribes snRNA genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
Show

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd4tm1Doi/Cd4tm1Litt,Lag3tm1Doi/Lag3+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pou2f2tm1Bal/Pou2f2+
Genetic Background: involves: 129S2/SvPas

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pou2f2tm1Bal/Pou2f2tm1Bal
Genetic Background: involves: 129S2/SvPas

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Pou2f2tm1Bal/Pou2f2tm1Bal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pou2f2tm1Bal/Pou2f2+
Genetic Background: involves: 129S2/SvPas

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou2f2tm1Bal/Pou2f2tm1Bal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Pou2f2tm1Bal/Pou2f2+
Genetic Background: involves: 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Pou2f2tm1Lmc/Pou2f2tm1Lmc
Genetic Background: involves: C57BL/6

Allelic Composition: Pou2f2tm1Bal/Pou2f2tm1Bal
Genetic Background: involves: 129S2/SvPas

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Tectm1Welm/Tectm1Welm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000061079 O70230 / Zfp143 / zinc finger protein 143 / P52747* / ZNF143*  / complex
 ENSMUSG00000001280 Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*  / complex






 

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