ENSMUSG00000048349


Mus musculus

Features
Gene ID: ENSMUSG00000048349
  
Biological name :Pou4f1
  
Synonyms : P17208 / Pou4f1 / POU domain, class 4, transcription factor 1
  
Possible biological names infered from orthology : POU class 4 homeobox 1 / Q01851
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E2.3
Gene start: 104461676
Gene end: 104467999
  
Corresponding Affymetrix probe sets: 10422179 (MoGene1.0st)   1429667_at (Mouse Genome 430 2.0 Array)   1429668_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060798
NCBI entrez gene - 18996     See in Manteia.
MGI - MGI:102525
RefSeq - XM_006518706
RefSeq - NM_011143
RefSeq - XM_006518705
RefSeq Peptide - NP_035273
swissprot - P17208
Ensembl - ENSMUSG00000048349
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou4f1ENSDARG00000005559Danio rerio
 POU4F1ENSGALG00000035441Gallus gallus
 POU4F1ENSG00000152192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168861
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449759
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551525
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685424
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849624
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201524
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*ENSMUSG0000009513924
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012523
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440622
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656522
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484222
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015584  POU domain, class 4, transcription factor 1
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IDA
 biological_processGO:0007498 mesoderm development IMP
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0021535 cell migration in hindbrain IMP
 biological_processGO:0021559 trigeminal nerve development IMP
 biological_processGO:0021953 central nervous system neuron differentiation IMP
 biological_processGO:0021986 habenula development IMP
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043069 negative regulation of programmed cell death IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045672 positive regulation of osteoclast differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048880 sensory system development IMP
 biological_processGO:0048934 peripheral nervous system neuron differentiation IMP
 biological_processGO:0048935 peripheral nervous system neuron development IGI
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051355 proprioception involved in equilibrioception IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0071158 positive regulation of cell cycle arrest IGI
 biological_processGO:0071345 cellular response to cytokine stimulus IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IDA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IDA
 biological_processGO:2001208 negative regulation of transcription elongation by RNA polymerase I IGI
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IGI
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IMP
 molecular_functionGO:0003714 transcription corepressor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0051020 GTPase binding IPI


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000840 abnormal epithalamus morphology "any malformation or absence of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj,Pou4f1tm1Et/Pou4f1tm1Et
Genetic Background: involves: 129 * C57BL/6

 MP:0000961 abnormal dorsal root ganglia morphology "malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]
Show

Allelic Composition: Snai1tm1Grid/Snai1tm2.1Grid
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0001083 small geniculate ganglion "reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
Show

Allelic Composition: Sema3btm1Cast/Sema3b+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6A

 MP:0001093 small trigeminal ganglion "reduced size of the trigeminal ganglion" [J:25565, J:17123]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001435 no suckling reflex "inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin" [J:56847]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: Mtortm1.1Koz/Mtortm1.1Koz
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj,Pou4f1tm1Et/Pou4f1tm1Et
Genetic Background: involves: 129 * C57BL/6

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leptm1Kry/Leptm1Kry
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aipl1tm1Visu/Aipl1tm1Visu,Tg(Crx-AIPL1*P351)#Visu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0003684 abnormal inferior olivary complex "any structural abnormality in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Srftm1.1Wtp/Srftm1.1Wtp
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL * Swiss Webster

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atf2tm1Glm/Atf2tm1Sis
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sema3btm1Cast/Sema3b+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6A

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj,Pou4f1tm1Et/Pou4f1tm1Et
Genetic Background: involves: 129 * C57BL/6

 MP:0012267 abnormal red nucleus morphology "any anomaly of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [MGI:anna]
Show

Allelic Composition: Dnase2atm1Aea/Dnase2atm1Aea
Genetic Background: involves: 129 * C57BL/6

 MP:0012268 absent red nucleus "absence of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination" [MGI:anna]
Show

Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr