ENSG00000152192


Homo sapiens

Features
Gene ID: ENSG00000152192
  
Biological name :POU4F1
  
Synonyms : POU4F1 / POU class 4 homeobox 1 / Q01851
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q31.1
Gene start: 78598362
Gene end: 78603560
  
Corresponding Affymetrix probe sets: 206940_s_at (Human Genome U133 Plus 2.0 Array)   211341_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000366413
NCBI entrez gene - 5457     See in Manteia.
OMIM - 601632
RefSeq - NM_006237
RefSeq Peptide - NP_006228
swissprot - Q01851
Ensembl - ENSG00000152192
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou4f1ENSDARG00000005559Danio rerio
 POU4F1ENSGALG00000035441Gallus gallus
 P17208ENSMUSG00000048349Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POU4F2 / Q12837 / POU class 4 homeobox 2ENSG0000015161561
POU4F3 / Q15319 / POU class 4 homeobox 3ENSG0000009101059
P20264 / POU3F3 / POU class 3 homeobox 3ENSG0000019891426
P09086 / POU2F2 / POU class 2 homeobox 2ENSG0000002827725
POU2F3 / Q9UKI9 / POU class 2 homeobox 3ENSG0000013770924
P49335 / POU3F4 / POU class 3 homeobox 4ENSG0000019676724
P20265 / POU3F2 / POU class 3 homeobox 2ENSG0000018448624
POU3F1 / Q03052 / POU class 3 homeobox 1ENSG0000018566823
P28069 / POU1F1 / POU class 1 homeobox 1ENSG0000006483522
Q06416 / POU5F1B / POU class 5 homeobox 1BENSG0000021299322
POU5F1 / Q01860 / POU class 5 homeobox 1ENSG0000020453122
P14859 / POU2F1 / POU class 2 homeobox 1ENSG0000014319022
POU5F2 / Q8N7G0 / POU domain class 5, transcription factor 2ENSG0000024848317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015584  POU domain, class 4, transcription factor 1
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0003223 ventricular compact myocardium morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis TAS
 biological_processGO:0007416 synapse assembly TAS
 biological_processGO:0007498 mesoderm development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021535 cell migration in hindbrain IEA
 biological_processGO:0021559 trigeminal nerve development IEA
 biological_processGO:0021953 central nervous system neuron differentiation IEA
 biological_processGO:0021986 habenula development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048665 neuron fate specification IEA
 biological_processGO:0048880 sensory system development IEA
 biological_processGO:0048934 peripheral nervous system neuron differentiation IEA
 biological_processGO:0048935 peripheral nervous system neuron development IEA
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051355 proprioception involved in equilibrioception IEA
 biological_processGO:0060384 innervation IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding IEA
 biological_processGO:2001208 negative regulation of transcription elongation by RNA polymerase I IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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