ENSG00000151615


Homo sapiens

Features
Gene ID: ENSG00000151615
  
Biological name :POU4F2
  
Synonyms : POU4F2 / POU class 4 homeobox 2 / Q12837
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q31.22
Gene start: 146638893
Gene end: 146642474
  
Corresponding Affymetrix probe sets: 207725_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000281321
NCBI entrez gene - 5458     See in Manteia.
OMIM - 113725
RefSeq - NM_004575
RefSeq Peptide - NP_004566
swissprot - Q12837
Ensembl - ENSG00000151615
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou4f2ENSDARG00000069737Danio rerio
 POU4F2ENSGALG00000037094Gallus gallus
 Pou4f2ENSMUSG00000031688Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POU4F1 / Q01851 / POU class 4 homeobox 1ENSG0000015219263
POU4F3 / Q15319 / POU class 4 homeobox 3ENSG0000009101060
P20264 / POU3F3 / POU class 3 homeobox 3ENSG0000019891428
P49335 / POU3F4 / POU class 3 homeobox 4ENSG0000019676725
P09086 / POU2F2 / POU class 2 homeobox 2ENSG0000002827725
Q06416 / POU5F1B / POU class 5 homeobox 1BENSG0000021299324
POU2F3 / Q9UKI9 / POU class 2 homeobox 3ENSG0000013770924
POU5F1 / Q01860 / POU class 5 homeobox 1ENSG0000020453124
P28069 / POU1F1 / POU class 1 homeobox 1ENSG0000006483523
P20265 / POU3F2 / POU class 3 homeobox 2ENSG0000018448623
POU3F1 / Q03052 / POU class 3 homeobox 1ENSG0000018566823
P14859 / POU2F1 / POU class 2 homeobox 1ENSG0000014319022
POU5F2 / Q8N7G0 / POU domain class 5, transcription factor 2ENSG0000024848319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000165 MAPK cascade IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0043068 positive regulation of programmed cell death ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048675 axon extension IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity ISS
 biological_processGO:0060041 retina development in camera-type eye IEA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:0071392 cellular response to estradiol stimulus ISS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator ISS
 biological_processGO:0090259 regulation of retinal ganglion cell axon guidance IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1902870 negative regulation of amacrine cell differentiation IEA
 biological_processGO:1990791 dorsal root ganglion development IEA
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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