ENSG00000143190


Homo sapiens

Features
Gene ID: ENSG00000143190
  
Biological name :POU2F1
  
Synonyms : P14859 / POU2F1 / POU class 2 homeobox 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q24.2
Gene start: 167220829
Gene end: 167427345
  
Corresponding Affymetrix probe sets: 206789_s_at (Human Genome U133 Plus 2.0 Array)   227254_at (Human Genome U133 Plus 2.0 Array)   229753_at (Human Genome U133 Plus 2.0 Array)   244006_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000401217
Ensembl peptide - ENSP00000404571
Ensembl peptide - ENSP00000453094
Ensembl peptide - ENSP00000441285
Ensembl peptide - ENSP00000415993
Ensembl peptide - ENSP00000414660
Ensembl peptide - ENSP00000271411
Ensembl peptide - ENSP00000356836
Ensembl peptide - ENSP00000356840
NCBI entrez gene - 5451     See in Manteia.
OMIM - 164175
RefSeq - NM_002697
RefSeq - XM_011509655
RefSeq - XM_011509654
RefSeq - XM_011509653
RefSeq - NM_001198783
RefSeq - NM_001198786
RefSeq Peptide - NP_001185712
RefSeq Peptide - NP_001185715
RefSeq Peptide - NP_002688
swissprot - A0A0A0MT46
swissprot - P14859
swissprot - Q16075
swissprot - A0A024R8Y2
swissprot - A0A0C4DG88
swissprot - A0A0A0MSV5
Ensembl - ENSG00000143190
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pou2f1bENSDARG00000007996Danio rerio
 POU2F1ENSGALG00000015446Gallus gallus
 P25425ENSMUSG00000026565Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P09086 / POU2F2 / POU class 2 homeobox 2ENSG0000002827733
POU2F3 / Q9UKI9 / POU class 2 homeobox 3ENSG0000013770928
P20264 / POU3F3 / POU class 3 homeobox 3ENSG0000019891420
P20265 / POU3F2 / POU class 3 homeobox 2ENSG0000018448618
P49335 / POU3F4 / POU class 3 homeobox 4ENSG0000019676718
POU5F1 / Q01860 / POU class 5 homeobox 1ENSG0000020453117
POU3F1 / Q03052 / POU class 3 homeobox 1ENSG0000018566817
Q06416 / POU5F1B / POU class 5 homeobox 1BENSG0000021299316
P28069 / POU1F1 / POU class 1 homeobox 1ENSG0000006483513
POU5F2 / Q8N7G0 / POU domain class 5, transcription factor 2ENSG0000024848312
POU4F1 / Q01851 / POU class 4 homeobox 1ENSG0000015219212
POU4F2 / Q12837 / POU class 4 homeobox 2ENSG0000015161512
POU4F3 / Q15319 / POU class 4 homeobox 3ENSG0000009101012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR000972  Octamer-binding transcription factor
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IMP
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-4 and Interleukin-13 signaling
RNA polymerase II transcribes snRNA genes
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104221 BRF2 / Q9HAW0 / BRF2, RNA polymerase III transcription initiation factor subunit  / complex / reaction
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / reaction / complex
 ENSG00000166478 P52747 / ZNF143 / zinc finger protein 143  / complex / reaction
 ENSG00000145734 BDP1 / A6H8Y1 / B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB  / reaction / complex






 

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