ENSMUSG00000095139


Mus musculus

Features
Gene ID: ENSMUSG00000095139
  
Biological name :Pou3f2
  
Synonyms : P31360 / Pou3f2 / POU domain, class 3, transcription factor 2
  
Possible biological names infered from orthology : P20265 / POU class 3 homeobox 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A3
Gene start: 22482780
Gene end: 22488366
  
Corresponding Affymetrix probe sets: 10511810 (MoGene1.0st)   10511812 (MoGene1.0st)   1450831_at (Mouse Genome 430 2.0 Array)   1453478_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136147
NCBI entrez gene - 18992     See in Manteia.
MGI - MGI:101895
RefSeq - NM_008899
RefSeq Peptide - NP_032925
swissprot - P31360
Ensembl - ENSMUSG00000095139
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P79746ENSDARG00000076262Danio rerio
 POU3F2ENSGALG00000038425Gallus gallus
 P20265ENSG00000184486Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*ENSMUSG0000004551560
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*ENSMUSG0000009012552
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*ENSMUSG0000005685450
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*ENSMUSG0000000849631
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*ENSMUSG0000002656530
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*ENSMUSG0000003201529
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*ENSMUSG0000002440625
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*ENSMUSG0000000484223
Pou4f3 / Q63955 / POU domain, class 4, transcription factor 3 / Q15319* / POU class 4 homeobox 3*ENSMUSG0000002449722
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*ENSMUSG0000004834922
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*ENSMUSG0000003168821
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*ENSMUSG0000009366818


Protein motifs (from Interpro)
Interpro ID Name
 IPR000327  POU-specific domain
 IPR001356  Homeobox domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR013847  POU domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016362  POU-domain transcription factor, class 3
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0014044 Schwann cell development IGI
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IGI
 biological_processGO:0021869 forebrain ventricular zone progenitor cell division IGI
 biological_processGO:0021979 hypothalamus cell differentiation IMP
 biological_processGO:0021985 neurohypophysis development IMP
 biological_processGO:0022011 myelination in peripheral nervous system IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0045595 regulation of cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048663 neuron fate commitment IDA
 biological_processGO:0048665 neuron fate specification IDA
 biological_processGO:0048666 neuron development IDA
 biological_processGO:0050770 regulation of axonogenesis IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Apobtm1Unc/Apob+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr,Pou3f2tm1Mejr/Pou3f2tm1Mejr,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001195 flaky skin "shedding scales on the skin " [J:56641]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rspo1tm1Mcch/Rspo1tm1Mcch
Genetic Background: involves: 129 * C57BL/6J

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f1tm1Mejr/Pou3f1tm2.1Mejr,Pou3f2tm1Mejr/Pou3f2tm1Mejr,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013340 abnormal pituicyte morphology "any structural anomaly of the distinctive fusiform cells present in the pars nervosa of the posterior pituitary gland which resemble astrocytes/glial cells of the CNS and assist in the storage and release of neurohypophysial hormones" [MGI:Anna]
Show

Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr