Manteia

ENSMUSG00000024497

Mus musculus

Features

Gene ID:	ENSMUSG00000024497

Biological name :	Pou4f3

Synonyms :	Pou4f3 / POU domain, class 4, transcription factor 3 / Q63955

Possible biological names infered from orthology :	POU class 4 homeobox 3 / Q15319

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	B3
Gene start:	42394539
Gene end:	42397249

Corresponding Affymetrix probe sets:	10455335 (MoGene1.0st) 1422353_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025374 NCBI entrez gene - 18998 See in Manteia. MGI - MGI:102523 RefSeq - NM_138945 RefSeq Peptide - NP_620395 swissprot - Q63955 Ensembl - ENSMUSG00000024497

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
pou4f3	ENSDARG00000006206	Danio rerio
POU4F3	ENSGALG00000043334	Gallus gallus
POU4F3	ENSG00000091010	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P17208 / Pou4f1 / POU domain, class 4, transcription factor 1 / Q01851* / POU class 4 homeobox 1*	ENSMUSG00000048349	73
Pou4f2 / Q63934 / POU domain, class 4, transcription factor 2 / Q12837* / POU class 4 homeobox 2*	ENSMUSG00000031688	72
P62515 / Pou3f4 / POU domain, class 3, transcription factor 4 / P49335* / POU class 3 homeobox 4*	ENSMUSG00000056854	31
P31361 / Pou3f3 / POU domain, class 3, transcription factor 3 / P20264* / POU class 3 homeobox 3*	ENSMUSG00000045515	31
P31360 / Pou3f2 / POU domain, class 3, transcription factor 2 / P20265* / POU class 3 homeobox 2*	ENSMUSG00000095139	29
P21952 / Pou3f1 / POU domain, class 3, transcription factor 1 / Q03052* / POU class 3 homeobox 1*	ENSMUSG00000090125	29
P20263 / Pou5f1 / POU domain, class 5, transcription factor 1 / Q06416* / Q01860* / POU5F1B* / POU class 5 homeobox 1* / POU class 5 homeobox 1B*	ENSMUSG00000024406	28
P25425 / Pou2f1 / POU domain, class 2, transcription factor 1 / P14859* / POU class 2 homeobox 1*	ENSMUSG00000026565	28
Pou2f2 / Q00196 / POU domain, class 2, transcription factor 2 / P09086* / POU class 2 homeobox 2*	ENSMUSG00000008496	28
Pou2f3 / POU domain, class 2, transcription factor 3 / Q9UKI9* / POU class 2 homeobox 3*	ENSMUSG00000032015	28
Pou1f1 / Q00286 / POU domain, class 1, transcription factor 1 / P28069* / POU class 1 homeobox 1*	ENSMUSG00000004842	27
Pou5f2 / POU domain class 5, transcription factor 2 / Q8N7G0*	ENSMUSG00000093668	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR000327	POU-specific domain
IPR001356	Homeobox domain
IPR001387	Cro/C1-type helix-turn-helix domain
IPR009057	Homeobox-like domain superfamily
IPR010982	Lambda repressor-like, DNA-binding domain superfamily
IPR013847	POU domain
IPR017970	Homeobox, conserved site
IPR032961	POU domain, class 4, transcription factor 3

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0007605	sensory perception of sound	IMP
biological_process	GO:0021562	vestibulocochlear nerve development	IMP
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0031290	retinal ganglion cell axon guidance	IGI
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0042491	inner ear auditory receptor cell differentiation	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0048675	axon extension	IGI
biological_process	GO:0048839	inner ear development	IMP
biological_process	GO:0050885	neuromuscular process controlling balance	IMP
biological_process	GO:0051402	neuron apoptotic process	IMP
biological_process	GO:0060113	inner ear receptor cell differentiation	IMP
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005667	transcription factor complex	IC
cellular_component	GO:0005737	cytoplasm	ISS
molecular_function	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	ISO
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO
molecular_function	GO:0003677	DNA binding	IDA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IDA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0043565	sequence-specific DNA binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000031	abnormal cochlea morphology	"any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000034	abnormal vestibule morphology	"malformed cavity between the semicircular canals and the cochlea of the inner ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk Genetic Background: Not Specified
MP:0000042	abnormal organ of Corti	"abnormalities associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0000043	organ of Corti degeneration	"a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000968	abnormal sensory neuron innervation	"defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
MP:0001410	head bobbing	"compulsive up and down movement of the head" [J:17123]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H
MP:0001516	abnormal motor coordination/ balance	"altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0001522	impaired swimming	"reduced ability or inability to swim" [J:45446, J:39081]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H
MP:0001525	impaired balance	"reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: H2-DMa^tm1Luc/H2-DMa^tm1Luc Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Mc1r^E-so/Mc1r^E-so Genetic Background: C3H
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ric8a^tm1.1Zhua/Ric8a^tm1.1Zhua,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lgr5^{tm1(cre/ERT2)Fjs}/Lgr5^{tm2(DTR/EGFP)Fjs},Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
MP:0002623	abnormal vestibular hair cell morphology	"malformation of the sensory epithelial cells of the membraneous labyrinth of the inner ear; these cells are in synaptic contact with the vestibular nerve" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0002855	abnormal cochlear ganglion morphology	"malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0002857	cochlear ganglion degeneration	"loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0003151	absent tunnel of Corti	"complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:32991]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0003152	abnormal pillar cell differentiation	"abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [J:32991, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003308	abnormal cochlear sensory epithelium		Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0003703	abnormal vestibulocochlear ganglion morphology	"malformed group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0003986	small cochlear ganglion	"reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0003987	small vestibular ganglion	"reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004298	vestibular ganglion degeneration	"loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004301	absent supporting cells	"absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004302	abnormal Dieters cell morphology	"any structural abnormality in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004306	small Rosenthal canal	"reduced size of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004308	abnormal basilar membrane	"any structural abnormality in the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004312	absent pillar cells	"absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004324	vestibular hair cell degeneration	"degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004325	absent vestibular hair cells	"absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0004328	decreased vestibular hair cell number	"decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0004362	cochlear hair cell degeneration	"degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004363	stria vascularis degeneration	"degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004393	abnormal cochlear inner hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell s surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004397	absent cochlear inner hair cells	"absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0004398	cochlear inner hair cell degeneration	"degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004399	abnormal cochlear outer hair cell morphology	"any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004403	absent cochlear outer hair cells	"absence of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004405	absent cochlear hair cells	"absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004409	abnormal neuroepithelium of ampullary crest	"any structural abnormality in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004465	degeneration of supporting cells	"degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0004515	abnormal vestibular hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0004518	absent vestibular hair cell stereocilia	"complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004526	absent cochlear hair cell stereocilia	"complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004527	abnormal outer hair cell stereociliary bundle morphology	"any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004530	absent outer hair cell stereocilia	"complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0004535	absent inner hair cell stereocilia	"complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004586	pillar cell degeneration	"degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0004588	abnormal vestibular hair cell development	"atypical initial production, differentiation, migration or maturation of hair cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004589	abnormal cochlear hair cell development	"atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004590	absent Dieters cells	"absence of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0004739	conductive hearing loss	"progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0004741	mixed hearing loss	"progressive reduction in the ability to hear resulting from a combination of conductive and sensorineural hearing loss" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Rubel}/Pou4f3⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
MP:0004742	abnormal vestibular system physiology	"any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may include impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk Genetic Background: Not Specified Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0005307	head tossing	"compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0005450	abnormal energy expenditure	"utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0006090	abnormal utricle morphology	"malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]	Show Allelic Composition: Pou4f3^{tm1.1(HBEGF)Jsto}/Pou4f3⁺ Genetic Background: either: (involves: 129S4/SvJaeSor * C57BL/6) or (involves: 129S4/SvJaeSor * CBA/J)
MP:0006276	abnormal autonomic nervous system physiology	"anomaly in the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controling involuntary bodily functions" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0006303	abnormal retinal nerve fiber layer morphology	"malformation of the layer of the retina formed by expansion of the fibers of the optic nerve" [ISBN:0-914294-08-3 "Gray s Anatomy", J:67382, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0006309	decreased retinal ganglion cell number	"reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J
MP:0008056	abnormal retinal ganglion cell morphology	"any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0008105	increased amacrine cell number	"increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0008304	abnormal supporting cell differentiation	"atypical production of or inability to produce the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0008507	thin retinal ganglion layer	"reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Pou4f2^tm3Whk/Pou4f2^tm3Whk,Pou4f3^tm1Whk/Pou4f3^tm1Whk Genetic Background: Not Specified
MP:0010015	abnormal cuticular plate morphology	"any structural anomaly of the firm laminar network of actin filaments in the organ of Corti to which the apical ends of the cochlear hair cells attach and through which their stereocilia project" [PMID:12324381]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae
MP:0011020	abnormal circadian temperature homeostasis	"any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]	Show Allelic Composition: Pou4f3^tm1Rsd/Pou4f3^tm1Rsd Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Pou4f2^tm1Rsd/Pou4f2^tm1Rsd Genetic Background: involves: 129S4/SvJae Allelic Composition: Pou4f3^tm1Xia/Pou4f3^tm1Xia Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Pou4f3^ddl/Pou4f3^ddl Genetic Background: C57BL/6J-Pou4f3^ddl/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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