ENSMUSG00000048562


Mus musculus

Features
Gene ID: ENSMUSG00000048562
  
Biological name :Sp8
  
Synonyms : Q8BMJ8 / Sp8 / Transcription factor Sp8
  
Possible biological names infered from orthology : Q8IXZ3 / Sp8 transcription factor
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F2
Gene start: 118846329
Gene end: 118852576
  
Corresponding Affymetrix probe sets: 10399189 (MoGene1.0st)   1440519_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065746
Ensembl peptide - ENSMUSP00000152523
NCBI entrez gene - 320145     See in Manteia.
MGI - MGI:2443471
RefSeq - XM_011244124
RefSeq - NM_177082
RefSeq - XM_006515985
RefSeq - XM_006515986
RefSeq - XM_006515987
RefSeq - XM_006515988
RefSeq - XM_006515983
RefSeq - XM_006515984
RefSeq Peptide - NP_796056
swissprot - Q5QR90
swissprot - Q8BMJ8
swissprot - A0A1Y7VJL2
Ensembl - ENSMUSG00000048562
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sp8aENSDARG00000011870Danio rerio
 SP8ENSGALG00000035725Gallus gallus
 SP8ENSG00000164651Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sp9 / Q64HY3 / Transcription factor Sp9 / P0CG40* / Sp9 transcription factor*ENSMUSG0000006885957
Sp6 / Q9ESX2 / trans-acting transcription factor 6 / Q3SY56* / Sp6 transcription factor*ENSMUSG0000003856031
Sp4 / Sp4 transcription factor / Q02446*ENSMUSG0000002532331
Sp1 / O89090 / Transcription factor Sp1 / P08047* / Sp1 transcription factor*ENSMUSG0000000128031
Sp7 / Q8VI67 / Mus musculus Sp7 transcription factor 7 (Sp7), transcript variant 2, mRNA. / Q8TDD2* / Sp7 transcription factor*ENSMUSG0000006028430
Sp5 / Q9JHX2 / Transcription factor Sp5 / Q6BEB4* / Sp5 transcription factor*ENSMUSG0000007530428
Sp3 / O70494 / Transcription factor Sp3 / Q02447* / Sp3 transcription factor*ENSMUSG0000002710928
Sp2 / Sp2 transcription factor / Q02086*ENSMUSG0000001867823
Klf11 / Q8K1S5 / Krueppel-like factor 11 / O14901* / Kruppel like factor 11*ENSMUSG0000002065320
Klf10 / O89091 / Mus musculus Kruppel-like factor 10 (Klf10), transcript variant 3, mRNA. / Q13118* / Kruppel like factor 10*ENSMUSG0000003746517
Klf16 / P58334 / Krueppel-like factor 16 / Q9BXK1* / Kruppel like factor 16*ENSMUSG0000003539715
Klf13 / Q9JJZ6 / Krueppel-like factor 13 / Q9Y2Y9* / Kruppel like factor 13*ENSMUSG0000005204015
Klf14 / Q19A41 / Krueppel-like factor 14 / Kruppel like factor 14*ENSMUSG0000007320914
Klf9 / Kruppel like factor 9 / Q13886*ENSMUSG0000003386314


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0009954 proximal/distal pattern formation IMP
 biological_processGO:0030326 embryonic limb morphogenesis IMP
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0000553 absent radius "missing the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54637]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000785 telencephalon hypoplasia "reduced cell number in cerebral cortex and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000850 absent cerebellum "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0002081 perinatal lethality "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(Fgf8)Lma/Gt(ROSA)26Sor+,Shhtm2(cre/ERT2)Cjt/Shhtm2(cre/ERT2)Cjt,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Gt(ROSA)26Sortm2(Sp8)Lma/Gt(ROSA)26Sor+,Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0002233 abnormal nose morphology "any structural anomaly of the organ that is specialized for smell and is part of the respiratory system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0002728 absent tibia "missing the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
Show

Allelic Composition: Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0003124 hypospadia "a urethral opening located closer to the base of the penis and not at the tip" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91491]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003315 abnormal perineum morphology "malformation in the area between the genital organs and the anus that lies beneath the pelvic diaphragm" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0003755 abnormal palate "anomaly in the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) " [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004619 caudal vertebral fusion "the union of one or more caudal vertebrae into a single structure in species where this does not normally occur" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0004653 absent caudal vertebrae "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004656 absent sacral vertebrae "absence of all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005296 abnormal humerus morphology "malformation of the bone of the forelimb that articulates with the scapula above and the radius and ulna below" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
Show

Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

Allelic Composition: Sp8tm1Smb/Sp8tm1Smb,Tg(Msx2-cre)5Rem/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008441 thin cortical plate "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009053 abnormal anal canal morphology "any structural abnormality in the terminal portion of the alimentary canal, which begins at the anorectal junction, where the rectal ampulla abruptly narrows as the alimentary canal pierces the pelvic diaphragm (levator ani), and ends at the anal verge, when the anoderm that lines the lower anal canal changes to hairy perianal skin; surrounded by the internal and external anal sphincters" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009947 abnormal olfactory bulb external plexiform layer morphology "any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs" [NLX:nlx_96 "NeuroLex.org"]
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0009950 abnormal olfactory bulb internal plexiform layer morphology 
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Allelic Composition: Ptk2tm1.1Itl/Ptk2tm1.1Itl
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Sp8tm2.1Aman/Sp8tm2.1Aman,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

 MP:0011771 abnormal genital tubercle morphology "any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation" [MGI:anna]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0011772 genital tubercle hypoplasia "underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells" [MGI:anna]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
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Allelic Composition: lgl/lgl+,Sp8tm1Smb/Sp8+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0012707 incomplete caudal neuropore closure "incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed" [MGI:anna]
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Allelic Composition: Gata3tm1Iho/Gata3tm1Iho,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0013164 abnormal forelimb bud morphology "any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species)" [MGI:anna]
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Allelic Composition: Sp8tm1Aman/Sp8tm1Aman
Genetic Background: involves: 129/Sv * NMRI

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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