ENSMUSG00000025369


Mus musculus

Features
Gene ID: ENSMUSG00000025369
  
Biological name :Smarcc2
  
Synonyms : Q6PDG5 / Smarcc2 / SWI/SNF complex subunit SMARCC2
  
Possible biological names infered from orthology : Q8TAQ2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128459248
Gene end: 128490482
  
Corresponding Affymetrix probe sets: 10367349 (MoGene1.0st)   1428382_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026433
Ensembl peptide - ENSMUSP00000096734
Ensembl peptide - ENSMUSP00000100868
Ensembl peptide - ENSMUSP00000151333
NCBI entrez gene - 68094     See in Manteia.
MGI - MGI:1915344
RefSeq - XM_006514024
RefSeq - NM_001114096
RefSeq - NM_001114097
RefSeq - NM_198160
RefSeq - XM_006514020
RefSeq - XM_006514021
RefSeq - XM_006514022
RefSeq - XM_006514023
RefSeq Peptide - NP_001107568
RefSeq Peptide - NP_001107569
RefSeq Peptide - NP_937803
swissprot - Q6PDG5
swissprot - A0A1W2P6N7
swissprot - Q3UID0
Ensembl - ENSMUSG00000025369
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smarcc2ENSDARG00000077946Danio rerio
 SMARCC2ENSGALG00000041592Gallus gallus
 Q8TAQ2ENSG00000139613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P97496 / Smarcc1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 / Q92922*ENSMUSG0000003248156


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001005  SANT/Myb domain
 IPR007526  SWIRM domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR032448  SMARCC, SWIRM-associated domain
 IPR032450  SMARCC, N-terminal
 IPR032451  SMARCC, C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006337 nucleosome disassembly ISO
 biological_processGO:0006338 chromatin remodeling ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016514 SWI/SNF complex ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 cellular_componentGO:0071564 npBAF complex IDA
 cellular_componentGO:0071565 nBAF complex IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000789 thickened cerebral cortex "Increased depth of the mantle coveringthe surface of the cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:49481]
Show

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0008547 abnormal neocortex morphology "any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]
Show

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0008946 abnormal neuron number "anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Ins2Akita/?
Genetic Background: involves: C57BL/6NSlc

Allelic Composition: Pax6tm2Pgr/Pax6tm2Pgr,Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0009430 increased embryo weight "increase in the weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Map2k1tm1Bacc/Map2k1tm1.1Bacc,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000561 Wdr77 / Q99J09 / WD repeat domain 77 / Q9BQA1*  / reaction / complex
 ENSMUSG00000023110 Prmt5 / protein arginine N-methyltransferase 5 / O14744* / protein arginine methyltransferase 5*  / reaction / complex
 ENSMUSG00000000902 Q9Z0H3 / Smarcb1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 / Q12824*  / complex
 ENSMUSG00000032481 P97496 / Smarcc1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 / Q92922*  / complex
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction






 

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