ENSMUSG00000023110


Mus musculus

Features
Gene ID: ENSMUSG00000023110
  
Biological name :Prmt5
  
Synonyms : Prmt5 / protein arginine N-methyltransferase 5
  
Possible biological names infered from orthology : O14744 / protein arginine methyltransferase 5
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C2
Gene start: 54507187
Gene end: 54517525
  
Corresponding Affymetrix probe sets: 10419759 (MoGene1.0st)   1427439_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154584
Ensembl peptide - ENSMUSP00000023873
Ensembl peptide - ENSMUSP00000121502
Ensembl peptide - ENSMUSP00000138549
NCBI entrez gene - 27374     See in Manteia.
MGI - MGI:1351645
RefSeq - NM_001313906
RefSeq - NM_001313907
RefSeq - NM_013768
RefSeq Peptide - NP_001300836
RefSeq Peptide - NP_038796
RefSeq Peptide - NP_001300835
swissprot - S4R295
swissprot - A0A0R4J049
swissprot - F6QQQ6
Ensembl - ENSMUSG00000023110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt5ENSDARG00000079605Danio rerio
 PRMT5ENSG00000100462Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007857  Protein arginine N-methyltransferase PRMT5
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR035075  PRMT5 arginine-N-methyltransferase
 IPR035247  PRMT5, TIM barrel domain
 IPR035248  PRMT5, oligomerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000387 spliceosomal snRNP assembly IEA
 biological_processGO:0006353 DNA-templated transcription, termination IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0018216 peptidyl-arginine methylation IEA
 biological_processGO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034969 histone arginine methylation IEA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0042118 endothelial cell activation IEA
 biological_processGO:0043985 histone H4-R3 methylation IEA
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090161 Golgi ribbon formation IEA
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034709 methylosome IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008327 methyl-CpG binding IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IEA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035243 protein-arginine omega-N symmetric methyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IEA
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prmt5tm2c(EUCOMM)Wtsi/Prmt5tm2c(EUCOMM)Wtsi,Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * 129S1/SvlmJ * C57BL/6Brd * C57BL/6N * SJL

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Msx2-rtTA)885Lma/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Nlgn3tm1.1Htz/Nlgn3tm1.1Htz
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex
 ENSMUSG00000006288 Ttc5 / Q99LG4 / tetratricopeptide repeat domain 5 / Q8N0Z6*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000000561 Wdr77 / Q99J09 / WD repeat domain 77 / Q9BQA1*  / complex / reaction
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex
 ENSMUSG00000032481 P97496 / Smarcc1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 / Q92922*  / complex / reaction
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / reaction / complex
 ENSMUSG00000000902 Q9Z0H3 / Smarcb1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 / Q12824*  / complex / reaction
 ENSMUSG00000025369 Q6PDG5 / Smarcc2 / SWI/SNF complex subunit SMARCC2 / Q8TAQ2* / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2*  / complex / reaction
 ENSMUSG00000031458 Coprs / Q9CQ13 / Coordinator of PRMT5 and differentiation stimulator / Q9NQ92*  / complex / reaction
 ENSMUSG00000021690 Jmy / junction mediating and regulatory protein, p53 cofactor / Q8N9B5*  / complex / reaction
 ENSMUSG00000055024 Ep300 / B2RWS6 / Histone acetyltransferase p300 / Q09472* / E1A binding protein p300*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr