ENSMUSG00000000561


Mus musculus

Features
Gene ID: ENSMUSG00000000561
  
Biological name :Wdr77
  
Synonyms : Q99J09 / Wdr77 / WD repeat domain 77
  
Possible biological names infered from orthology : Q9BQA1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 105959369
Gene end: 105970037
  
Corresponding Affymetrix probe sets: 10495111 (MoGene1.0st)   1422844_a_at (Mouse Genome 430 2.0 Array)   1430289_a_at (Mouse Genome 430 2.0 Array)   1434552_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120517
Ensembl peptide - ENSMUSP00000122465
Ensembl peptide - ENSMUSP00000010278
NCBI entrez gene - 70465     See in Manteia.
MGI - MGI:1917715
RefSeq - NM_027432
RefSeq Peptide - NP_081708
swissprot - Q99J09
swissprot - D6RIL4
swissprot - F7D5L2
Ensembl - ENSMUSG00000000561
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WDR77ENSGALG00000040864Gallus gallus
 WDR77ENSG00000116455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034709 methylosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008327 methyl-CpG binding IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IEA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000659 prostate gland hyperplasia "increased cell number in the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

 MP:0000666 reduced number of prostate ducts "fewer than normal minute canals that pass the prostatic secretions to the urethra" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0001163 abnormal coagulating gland "malformed or malfunctioning anterior lobe of the prostate" [J:64981]
Show

Allelic Composition: T/twPas1
Genetic Background: involves: BTBR/Nev T * M. m. brevirostris

 MP:0001167 prostate epithelial hyperplasia "epithelium is multi-layered instead of columnar with increased cell number" [J:63764]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: T/twPas1
Genetic Background: involves: BTBR/Nev T * M. m. brevirostris

 MP:0002774 small prostate "reduced size of the gland in males that secretes part of the seminiferous fluid" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0003607 abnormal prostate physiology "malfunction of the gland in males that secretes part of the seminiferous fluid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0009380 abnormal ventral prostate morphology 
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0009381 abnormal dorsolateral prostate morphology 
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0009734 abnormal prostate gland duct morphology "any structural anomaly of the minute canals that pass the prostatic secretions to the urethra" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0009735 abnormal prostate gland development "anomaly in the formation or pattering of the of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0009736 abnormal prostate gland branching morphogenesis "anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wdr77tm2Zwan/Wdr77tm2Zwan,Tg(Pbsn-cre)20Fwan/0
Genetic Background: involves: C57BL/6J * FVB/NCrl

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Mib1tm1Kong/Mib1tm1Kong
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006728 Cdk4 / P30285 / Cyclin-dependent kinase 4 / P11802*  / complex
 ENSMUSG00000032187 Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*  / complex / reaction
 ENSMUSG00000032481 P97496 / Smarcc1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 / Q92922*  / complex / reaction
 ENSMUSG00000000902 Q9Z0H3 / Smarcb1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 / Q12824*  / reaction / complex
 ENSMUSG00000070348 Ccnd1 / P25322 / G1/S-specific cyclin-D1 / P24385* / cyclin D1*  / complex
 ENSMUSG00000025369 Q6PDG5 / Smarcc2 / SWI/SNF complex subunit SMARCC2 / Q8TAQ2* / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2*  / reaction / complex
 ENSMUSG00000023110 Prmt5 / protein arginine N-methyltransferase 5 / O14744* / protein arginine methyltransferase 5*  / reaction / complex
 ENSMUSG00000031458 Coprs / Q9CQ13 / Coordinator of PRMT5 and differentiation stimulator / Q9NQ92*  / reaction / complex






 

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