ENSG00000116455


Homo sapiens

Features
Gene ID: ENSG00000116455
  
Biological name :WDR77
  
Synonyms : Q9BQA1 / WDR77 / WD repeat domain 77
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p13.2
Gene start: 111439890
Gene end: 111449376
  
Corresponding Affymetrix probe sets: 201420_s_at (Human Genome U133 Plus 2.0 Array)   201421_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409300
Ensembl peptide - ENSP00000235090
NCBI entrez gene - 79084     See in Manteia.
OMIM - 611734
RefSeq - NM_001317063
RefSeq - NM_001317062
RefSeq - NM_001317064
RefSeq - NM_024102
RefSeq Peptide - NP_001303992
RefSeq Peptide - NP_001303991
RefSeq Peptide - NP_077007
RefSeq Peptide - NP_001303993
swissprot - Q9BQA1
swissprot - H0Y711
swissprot - A0A024R0H7
Ensembl - ENSG00000116455
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 WDR77ENSGALG00000040864Gallus gallus
 Wdr77ENSMUSG00000000561Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000387 spliceosomal snRNP assembly TAS
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA
 biological_processGO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA
 cellular_componentGO:0005634 nucleus IGI
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IGI
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0034709 methylosome IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008327 methyl-CpG binding IDA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity TAS
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IGI


Pathways (from Reactome)
Pathway description
snRNP Assembly
RMTs methylate histone arginines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / complex / reaction
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / complex
 ENSG00000080503 P51531 / SMARCA2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2  / complex / reaction
 ENSG00000099956 Q12824 / SMARCB1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1  / reaction / complex
 ENSG00000173473 Q92922 / SMARCC1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1  / complex / reaction
 ENSG00000139613 Q8TAQ2 / SMARCC2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2  / complex / reaction
 ENSG00000127616 P51532 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4  / complex / reaction
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / complex
 ENSG00000074201 CLNS1A / P54105 / chloride nucleotide-sensitive channel 1A  / complex
 ENSG00000172301 COPRS / Q9NQ92 / coordinator of PRMT5 and differentiation stimulator  / reaction / complex






 

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