ENSG00000100462


Homo sapiens

Features
Gene ID: ENSG00000100462
  
Biological name :PRMT5
  
Synonyms : O14744 / PRMT5 / protein arginine methyltransferase 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q11.2
Gene start: 22920511
Gene end: 22929585
  
Corresponding Affymetrix probe sets: 1564520_s_at (Human Genome U133 Plus 2.0 Array)   1564521_x_at (Human Genome U133 Plus 2.0 Array)   217786_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452555
Ensembl peptide - ENSP00000452509
Ensembl peptide - ENSP00000485787
Ensembl peptide - ENSP00000216350
Ensembl peptide - ENSP00000319169
Ensembl peptide - ENSP00000380582
Ensembl peptide - ENSP00000380583
Ensembl peptide - ENSP00000387663
Ensembl peptide - ENSP00000409482
Ensembl peptide - ENSP00000450633
Ensembl peptide - ENSP00000450737
Ensembl peptide - ENSP00000450919
Ensembl peptide - ENSP00000450956
Ensembl peptide - ENSP00000451127
Ensembl peptide - ENSP00000451245
Ensembl peptide - ENSP00000452102
Ensembl peptide - ENSP00000452218
Ensembl peptide - ENSP00000452409
Ensembl peptide - ENSP00000452411
Ensembl peptide - ENSP00000452501
NCBI entrez gene - 10419     See in Manteia.
OMIM - 604045
RefSeq - NM_001282953
RefSeq - NM_001039619
RefSeq - NM_001282954
RefSeq - NM_001282955
RefSeq - NM_001282956
RefSeq - NM_006109
RefSeq - XM_017020927
RefSeq Peptide - NP_001269884
RefSeq Peptide - NP_001269885
RefSeq Peptide - NP_006100
RefSeq Peptide - NP_001269883
RefSeq Peptide - NP_001034708
RefSeq Peptide - NP_001269882
swissprot - H7BZ44
swissprot - C9JSX3
swissprot - O14744
swissprot - G3V2F5
swissprot - G3V2L6
swissprot - G3V2X6
swissprot - G3V3A3
swissprot - G3V507
swissprot - G3V5L5
swissprot - G3V580
swissprot - G3V5T6
swissprot - H0YJ77
swissprot - H0YJD3
swissprot - H0YJX6
swissprot - H0YJY6
Ensembl - ENSG00000100462
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt5ENSDARG00000079605Danio rerio
 Prmt5ENSMUSG00000023110Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007857  Protein arginine N-methyltransferase PRMT5
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR035075  PRMT5 arginine-N-methyltransferase
 IPR035247  PRMT5, TIM barrel domain
 IPR035248  PRMT5, oligomerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000387 spliceosomal snRNP assembly TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006353 DNA-templated transcription, termination IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0018216 peptidyl-arginine methylation IMP
 biological_processGO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0042118 endothelial cell activation IMP
 biological_processGO:0043985 histone H4-R3 methylation NAS
 biological_processGO:0044030 regulation of DNA methylation IEA
 biological_processGO:0045596 negative regulation of cell differentiation IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090161 Golgi ribbon formation IMP
 biological_processGO:0097421 liver regeneration IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:1904992 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0034709 methylosome IDA
 cellular_componentGO:0035097 histone methyltransferase complex IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003714 transcription corepressor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008327 methyl-CpG binding IDA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity TAS
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035243 protein-arginine omega-N symmetric methyltransferase activity EXP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043021 ribonucleoprotein complex binding IPI
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) IMP
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
snRNP Assembly
RMTs methylate histone arginines
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / complex
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / complex
 ENSG00000173473 Q92922 / SMARCC1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1  / reaction / complex
 ENSG00000139613 Q8TAQ2 / SMARCC2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2  / reaction / complex
 ENSG00000116455 WDR77 / Q9BQA1 / WD repeat domain 77  / complex / reaction
 ENSG00000136319 TTC5 / Q8N0Z6 / tetratricopeptide repeat domain 5  / reaction / complex
 ENSG00000080503 P51531 / SMARCA2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2  / reaction / complex
 ENSG00000099956 Q12824 / SMARCB1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1  / reaction / complex
 ENSG00000152409 JMY / Q8N9B5 / junction mediating and regulatory protein, p53 cofactor  / reaction / complex
 ENSG00000127616 P51532 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000074201 CLNS1A / P54105 / chloride nucleotide-sensitive channel 1A  / complex
 ENSG00000172301 COPRS / Q9NQ92 / coordinator of PRMT5 and differentiation stimulator  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction






 

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