ENSG00000136319


Homo sapiens

Features
Gene ID: ENSG00000136319
  
Biological name :TTC5
  
Synonyms : Q8N0Z6 / tetratricopeptide repeat domain 5 / TTC5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q11.2
Gene start: 20256558
Gene end: 20305994
  
Corresponding Affymetrix probe sets: 1558605_at (Human Genome U133 Plus 2.0 Array)   1558606_s_at (Human Genome U133 Plus 2.0 Array)   226557_at (Human Genome U133 Plus 2.0 Array)   243007_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000451259
Ensembl peptide - ENSP00000258821
Ensembl peptide - ENSP00000372496
NCBI entrez gene - 91875     See in Manteia.
RefSeq - NM_138376
RefSeq Peptide - NP_612385
swissprot - Q8N0Z6
swissprot - G3V3I6
swissprot - H9KV81
Ensembl - ENSG00000136319
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttc5ENSDARG00000013329Danio rerio
 Ttc5ENSMUSG00000006288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR019734  Tetratricopeptide repeat
 IPR023392  Mitochondrial outer membrane translocase complex, Tom20 domain superfamily
 IPR032076  Tetratricopeptide repeat protein 5, OB fold domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction / complex
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction
 ENSG00000183765 CHEK2 / O96017 / checkpoint kinase 2  / reaction
 ENSG00000152409 JMY / Q8N9B5 / junction mediating and regulatory protein, p53 cofactor  / reaction / complex






 

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