ENSG00000152409


Homo sapiens

Features
Gene ID: ENSG00000152409
  
Biological name :JMY
  
Synonyms : JMY / junction mediating and regulatory protein, p53 cofactor / Q8N9B5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q14.1
Gene start: 79236189
Gene end: 79327215
  
Corresponding Affymetrix probe sets: 226352_at (Human Genome U133 Plus 2.0 Array)   241985_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379441
NCBI entrez gene - 133746     See in Manteia.
OMIM - 604279
RefSeq - XM_011543155
RefSeq - NM_152405
RefSeq - XM_005248430
RefSeq Peptide - NP_689618
swissprot - Q8N9B5
Ensembl - ENSG00000152409
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JMYENSDARG00000114796Danio rerio
 JMYENSGALG00000014819Gallus gallus
 JmyENSMUSG00000021690Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WHAMM / Q8TF30 / WAS protein homolog associated with actin, golgi membranes and microtubulesENSG0000015623230


Protein motifs (from Interpro)
Interpro ID Name
 IPR003124  WH2 domain
 IPR031738  JMY/WHAMM, middle domain
 IPR031808  JMY/WHAMM, N-terminal
 IPR033324  Junction-mediating and -regulatory protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007050 cell cycle arrest IBA
 biological_processGO:0034314 Arp2/3 complex-mediated actin nucleation IBA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IBA
 biological_processGO:0070060 "de novo" actin filament nucleation IBA
 biological_processGO:0070358 actin polymerization-dependent cell motility ISS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031252 cell leading edge IDA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0071933 Arp2/3 complex binding IBA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / complex / reaction
 ENSG00000136319 TTC5 / Q8N0Z6 / tetratricopeptide repeat domain 5  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / complex / reaction






 

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