ENSG00000139613


Homo sapiens

Features
Gene ID: ENSG00000139613
  
Biological name :SMARCC2
  
Synonyms : Q8TAQ2 / SMARCC2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.2
Gene start: 56162983
Gene end: 56189567
  
Corresponding Affymetrix probe sets: 1561973_at (Human Genome U133 Plus 2.0 Array)   201320_at (Human Genome U133 Plus 2.0 Array)   201321_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449396
Ensembl peptide - ENSP00000447680
Ensembl peptide - ENSP00000449429
Ensembl peptide - ENSP00000267064
Ensembl peptide - ENSP00000302919
Ensembl peptide - ENSP00000377591
NCBI entrez gene - 6601     See in Manteia.
OMIM - 601734
RefSeq - XM_017019887
RefSeq - XM_005269101
RefSeq - XM_005269102
RefSeq - XM_005269103
RefSeq - XM_005269104
RefSeq - XM_011538693
RefSeq - XM_017019884
RefSeq - XM_017019885
RefSeq - XM_017019886
RefSeq - NM_001130420
RefSeq - NM_003075
RefSeq - NM_139067
RefSeq Peptide - NP_620706
RefSeq Peptide - NP_001123892
RefSeq Peptide - NP_001317217
RefSeq Peptide - NP_003066
swissprot - A0A024RB22
swissprot - F8VZW6
swissprot - Q8TAQ2
swissprot - F8VXC8
Ensembl - ENSG00000139613
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smarcc2ENSDARG00000077946Danio rerio
 SMARCC2ENSGALG00000041592Gallus gallus
 Q6PDG5ENSMUSG00000025369Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q92922 / SMARCC1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1ENSG0000017347355


Protein motifs (from Interpro)
Interpro ID Name
 IPR000953  Chromo/chromo shadow domain
 IPR001005  SANT/Myb domain
 IPR007526  SWIRM domain
 IPR009057  Homeobox-like domain superfamily
 IPR017884  SANT domain
 IPR032448  SMARCC, SWIRM-associated domain
 IPR032450  SMARCC, N-terminal
 IPR032451  SMARCC, C-terminal
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036420  BRCT domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006337 nucleosome disassembly IDA
 biological_processGO:0006338 chromatin remodeling IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II NAS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling HDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 cellular_componentGO:0000790 nuclear chromatin HDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016514 SWI/SNF complex IDA
 cellular_componentGO:0017053 transcriptional repressor complex IPI
 cellular_componentGO:0032991 protein-containing complex HDA
 cellular_componentGO:0071564 npBAF complex ISS
 cellular_componentGO:0071565 nBAF complex ISS
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding HDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding HDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding HDA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100462 PRMT5 / O14744 / protein arginine methyltransferase 5  / reaction / complex
 ENSG00000116455 WDR77 / Q9BQA1 / WD repeat domain 77  / complex / reaction
 ENSG00000173473 Q92922 / SMARCC1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1  / complex
 ENSG00000099956 Q12824 / SMARCB1 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1  / complex
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / complex / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / complex / reaction
 ENSG00000080503 P51531 / SMARCA2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2  / complex
 ENSG00000127616 P51532 / SMARCA4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4  / complex






 

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