ENSMUSG00000109324


Mus musculus

Features
Gene ID: ENSMUSG00000109324
  
Biological name :Prmt1
  
Synonyms : Prmt1 / protein arginine N-methyltransferase 1 / Q9JIF0
  
Possible biological names infered from orthology : protein arginine methyltransferase 1 / Q99873
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 44975989
Gene end: 44986568
  
Corresponding Affymetrix probe sets: 10563014 (MoGene1.0st)   1452787_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103474
Ensembl peptide - ENSMUSP00000147252
Ensembl peptide - ENSMUSP00000147201
Ensembl peptide - ENSMUSP00000147193
Ensembl peptide - ENSMUSP00000147101
Ensembl peptide - ENSMUSP00000147098
Ensembl peptide - ENSMUSP00000146804
Ensembl peptide - ENSMUSP00000146655
Ensembl peptide - ENSMUSP00000146526
Ensembl peptide - ENSMUSP00000146395
Ensembl peptide - ENSMUSP00000045365
NCBI entrez gene - 15469     See in Manteia.
MGI - MGI:107846
RefSeq - XM_011250807
RefSeq - NM_001252476
RefSeq - NM_001252477
RefSeq - NM_019830
RefSeq - XM_006540640
RefSeq Peptide - NP_001239406
RefSeq Peptide - NP_062804
RefSeq Peptide - NP_001239405
swissprot - A0A140LJG1
swissprot - Q3UIG8
swissprot - Q9JIF0
swissprot - A0A171KXD3
swissprot - A0A140LJF4
swissprot - A0A140LJ70
swissprot - A0A140LJ68
swissprot - A0A140LI33
swissprot - A0A140LIF7
swissprot - A0A140LHS4
swissprot - A0A140LHF7
Ensembl - ENSMUSG00000109324
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt1ENSDARG00000010246Danio rerio
 PRMT1ENSG00000126457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prmt8 / Q6PAK3 / protein arginine N-methyltransferase 8 / Q9NR22* / protein arginine methyltransferase 8*ENSMUSG0000003035078
Prmt3 / Q922H1 / protein arginine N-methyltransferase 3 / O60678* / protein arginine methyltransferase 3*ENSMUSG0000003050545
Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*ENSMUSG0000003218535
Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*ENSMUSG0000004930032
Prmt2 / protein arginine N-methyltransferase 2 / P55345* / protein arginine methyltransferase 2*ENSMUSG0000002023031


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0018216 peptidyl-arginine methylation ISO
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine ISO
 biological_processGO:0031175 neuron projection development ISO
 biological_processGO:0032259 methylation IEA
 biological_processGO:0035247 peptidyl-arginine omega-N-methylation ISO
 biological_processGO:0043985 histone H4-R3 methylation IBA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISO
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0034709 methylosome ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008170 N-methyltransferase activity ISS
 molecular_functionGO:0008276 protein methyltransferase activity ISO
 molecular_functionGO:0008327 methyl-CpG binding ISS
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity ISO
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity ISO
 molecular_functionGO:0016275 [cytochrome c]-arginine N-methyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0035241 protein-arginine omega-N monomethyltransferase activity ISO
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISO
 molecular_functionGO:0042054 histone methyltransferase activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) ISO
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding ISO


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001710 absent amniotic folds "failure of amnion to form involutions" [J:40594]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Prkab1tm1a(KOMP)Wtsi/Prkab1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1a(KOMP)Wtsi/Wtsi

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Prmt1tm1.1Rchd/Prmt1tm1.1Rchd
Genetic Background: involves: 129 * C57BL/6J

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011207 absent ectoplacental cavity "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
Show

Allelic Composition: Tnfsf13btm1Msc/Tnfsf13b+
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex / reaction
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / complex / reaction
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / complex / reaction
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / complex / reaction
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / complex / reaction
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction / complex






 

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