ENSMUSG00000032185


Mus musculus

Features
Gene ID: ENSMUSG00000032185
  
Biological name :Carm1
  
Synonyms : Carm1 / Histone-arginine methyltransferase CARM1 / Q9WVG6
  
Possible biological names infered from orthology : coactivator associated arginine methyltransferase 1 / Q86X55
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 21546894
Gene end: 21592623
  
Corresponding Affymetrix probe sets: 10583676 (MoGene1.0st)   1419743_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000111052
Ensembl peptide - ENSMUSP00000150181
Ensembl peptide - ENSMUSP00000117243
Ensembl peptide - ENSMUSP00000111053
Ensembl peptide - ENSMUSP00000034703
NCBI entrez gene - 59035     See in Manteia.
MGI - MGI:1913208
RefSeq - NM_153141
RefSeq - NM_021531
RefSeq Peptide - NP_067506
RefSeq Peptide - NP_694781
swissprot - Q9WVG6
swissprot - D3YUP1
swissprot - A0A1L1ST60
swissprot - D6RFA7
Ensembl - ENSMUSG00000032185
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carm1ENSDARG00000018698Danio rerio
 CARM1ENSG00000142453Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prmt3 / Q922H1 / protein arginine N-methyltransferase 3 / O60678* / protein arginine methyltransferase 3*ENSMUSG0000003050523
Prmt8 / Q6PAK3 / protein arginine N-methyltransferase 8 / Q9NR22* / protein arginine methyltransferase 8*ENSMUSG0000003035021
Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*ENSMUSG0000010932421
Prmt2 / protein arginine N-methyltransferase 2 / P55345* / protein arginine methyltransferase 2*ENSMUSG0000002023021
Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*ENSMUSG0000004930019


Protein motifs (from Interpro)
Interpro ID Name
 IPR020989  Histone-arginine methyltransferase CARM1, N-terminal
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003420 regulation of growth plate cartilage chondrocyte proliferation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016571 histone methylation ISO
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IDA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IGI
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0034969 histone arginine methylation IDA
 biological_processGO:0034970 histone H3-R2 methylation ISO
 biological_processGO:0034971 histone H3-R17 methylation IDA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060350 endochondral bone morphogenesis IMP
 biological_processGO:0071168 protein localization to chromatin IMP
 biological_processGO:1902415 regulation of mRNA binding IEA
 biological_processGO:2000171 negative regulation of dendrite development IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008276 protein methyltransferase activity IDA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity ISO
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IDA
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IDA
 molecular_functionGO:0035642 histone methyltransferase activity (H3-R17 specific) IDA
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IMP
 molecular_functionGO:0070577 lysine-acetylated histone binding IDA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Sall1tm4.1Ryn/Sall1tm4.1Ryn,Sall4tm3Ryn/Sall4tm4Ryn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall1tm4.1Ryn/Sall1tm4.1Ryn,Sall4tm3Ryn/Sall4tm4Ryn
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Carm1tm1Mtb/Carm1tm1Mtb
Genetic Background: involves: 129S6/SvEvTac

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

Allelic Composition: Carm1tm2.1Mtb/Carm1tm2.1Mtb
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Carm1tm2.1Mtb/Carm1tm2.1Mtb
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

Allelic Composition: Carm1tm1Mtb/Carm1tm1Mtb
Genetic Background: involves: 129S6/SvEvTac

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacna1btm1b(KOMP)Wtsi/Cacna1btm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cacna1btm1b(KOMP)Wtsi/H

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Cdh23v-8J/Cdh23v-8J
Genetic Background: C57BL/6J-Cdh23v-8J/J

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Carm1tm2.1Mtb/Carm1tm2.1Mtb
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

Allelic Composition: Carm1tm1Mtb/Carm1tm1Mtb
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014767 Tbp / P29037 / TATA box binding protein / P20226*  / reaction / complex
 ENSMUSG00000020962 Gtf2a1 / Q99PM3 / Transcription initiation factor IIA subunit 1 Transcription initiation factor IIA alpha chain Transcription initiation factor IIA beta chain / P52655* / general transcript...  / reaction / complex
 ENSMUSG00000035451 Foxa1 / P35582 / Hepatocyte nuclear factor 3-alpha / P55317* / forkhead box A1*  / complex / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / reaction / complex
 ENSMUSG00000015619 Gata3 / P23772 / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA. / P23771* / GATA binding protein 3*  / reaction / complex
 ENSMUSG00000033543 Gtf2a2 / Q80ZM7 / Transcription initiation factor IIA subunit 2 / P52657* / general transcription factor IIA subunit 2*  / complex / reaction






 

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