ENSMUSG00000030350


Mus musculus

Features
Gene ID: ENSMUSG00000030350
  
Biological name :Prmt8
  
Synonyms : Prmt8 / protein arginine N-methyltransferase 8 / Q6PAK3
  
Possible biological names infered from orthology : protein arginine methyltransferase 8 / Q9NR22
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 127689011
Gene end: 127769472
  
Corresponding Affymetrix probe sets: 10548118 (MoGene1.0st)   1435204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032500
NCBI entrez gene - 381813     See in Manteia.
MGI - MGI:3043083
RefSeq - NM_201371
RefSeq - XM_006506352
RefSeq Peptide - NP_958759
swissprot - Q6PAK3
Ensembl - ENSMUSG00000030350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRMT8ENSDARG00000040633Danio rerio
 prmt8bENSDARG00000045760Danio rerio
 PRMT8ENSGALG00000013272Gallus gallus
 PRMT8ENSG00000111218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*ENSMUSG0000010932473
Prmt3 / Q922H1 / protein arginine N-methyltransferase 3 / O60678* / protein arginine methyltransferase 3*ENSMUSG0000003050542
Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*ENSMUSG0000003218532
Prmt2 / protein arginine N-methyltransferase 2 / P55345* / protein arginine methyltransferase 2*ENSMUSG0000002023030
Prmt6 / Q6NZB1 / protein arginine N-methyltransferase 6 / Q96LA8* / protein arginine methyltransferase 6*ENSMUSG0000004930029


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0018216 peptidyl-arginine methylation IEA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034969 histone arginine methylation IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IEA
 molecular_functionGO:0008757 S-adenosylmethionine-dependent methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035241 protein-arginine omega-N monomethyltransferase activity IEA
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Prmt8tm1d(EUCOMM)Wtsi/Prmt8+
Genetic Background: involves: C57BL/6N

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cap2tm1c(EUCOMM)Wtsi/Cap2tm1c(EUCOMM)Wtsi,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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