ENSMUSG00000049300


Mus musculus

Features
Gene ID: ENSMUSG00000049300
  
Biological name :Prmt6
  
Synonyms : Prmt6 / protein arginine N-methyltransferase 6 / Q6NZB1
  
Possible biological names infered from orthology : protein arginine methyltransferase 6 / Q96LA8
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F3
Gene start: 110246109
Gene end: 110250998
  
Corresponding Affymetrix probe sets: 10501485 (MoGene1.0st)   1425059_at (Mouse Genome 430 2.0 Array)   1434209_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102177
Ensembl peptide - ENSMUSP00000129801
Ensembl peptide - ENSMUSP00000140836
NCBI entrez gene - 99890     See in Manteia.
MGI - MGI:2139971
RefSeq - NM_178891
RefSeq Peptide - NP_849222
swissprot - Q6NZB1
Ensembl - ENSMUSG00000049300
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt6ENSDARG00000069706Danio rerio
 PRMT6ENSG00000198890Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prmt2 / protein arginine N-methyltransferase 2 / P55345* / protein arginine methyltransferase 2*ENSMUSG0000002023034
Carm1 / Q9WVG6 / Histone-arginine methyltransferase CARM1 / Q86X55* / coactivator associated arginine methyltransferase 1*ENSMUSG0000003218531
Prmt1 / Q9JIF0 / protein arginine N-methyltransferase 1 / Q99873* / protein arginine methyltransferase 1*ENSMUSG0000010932431
Prmt8 / Q6PAK3 / protein arginine N-methyltransferase 8 / Q9NR22* / protein arginine methyltransferase 8*ENSMUSG0000003035030
Prmt3 / Q922H1 / protein arginine N-methyltransferase 3 / O60678* / protein arginine methyltransferase 3*ENSMUSG0000003050530


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016571 histone methylation IEA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034970 histone H3-R2 methylation IEA
 biological_processGO:0043985 histone H4-R3 methylation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0090398 cellular senescence IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IEA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035241 protein-arginine omega-N monomethyltransferase activity IEA
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IEA
 molecular_functionGO:0042054 histone methyltransferase activity IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) IEA
 molecular_functionGO:0070611 histone methyltransferase activity (H3-R2 specific) IEA
 molecular_functionGO:0070612 histone methyltransferase activity (H2A-R3 specific) IEA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+,Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+,Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042557 Sin3a / Q60520 / Mus musculus transcriptional regulator, SIN3A (yeast) (Sin3a), transcript variant 4, mRNA. / Q96ST3* / SIN3 transcription regulator family member A*  / complex / reaction
 ENSMUSG00000100210 P84228 / Hist1h3f / Histone H3.2   / complex
 ENSMUSG00000099517 P68433 / Hist1h3g / Histone H3.1   / complex
 ENSMUSG00000060743 H3f3a / P84244 / Histone H3.3 / P84243* / H3 histone family member 3A*  / complex
 ENSMUSG00000028800 Hdac1 / O09106 / Histone deacetylase 1 / Q13547*  / reaction / complex
 ENSMUSG00000060981 P62806 / Hist1h4h / Histone H4   / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / reaction / complex
 ENSMUSG00000061062 Gm10093 / HDAC1* / Q13547* / histone deacetylase 1*  / reaction / complex






 

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