ENSG00000198890


Homo sapiens

Features
Gene ID: ENSG00000198890
  
Biological name :PRMT6
  
Synonyms : PRMT6 / protein arginine methyltransferase 6 / Q96LA8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p13.3
Gene start: 107056679
Gene end: 107059294
  
Corresponding Affymetrix probe sets: 223275_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359095
NCBI entrez gene - 55170     See in Manteia.
OMIM - 608274
RefSeq - NM_018137
RefSeq Peptide - NP_060607
swissprot - Q96LA8
Ensembl - ENSG00000198890
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt6ENSDARG00000069706Danio rerio
 Prmt6ENSMUSG00000049300Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRMT2 / P55345 / protein arginine methyltransferase 2ENSG0000016031035
CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1ENSG0000014245332
PRMT8 / Q9NR22 / protein arginine methyltransferase 8ENSG0000011121831
PRMT1 / Q99873 / protein arginine methyltransferase 1ENSG0000012645730
PRMT3 / O60678 / protein arginine methyltransferase 3ENSG0000018523829


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair TAS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034970 histone H3-R2 methylation IDA
 biological_processGO:0043985 histone H4-R3 methylation IEA
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0090398 cellular senescence IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IDA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035241 protein-arginine omega-N monomethyltransferase activity IDA
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IDA
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0042393 histone binding IDA
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) IDA
 molecular_functionGO:0070611 histone methyltransferase activity (H3-R2 specific) IDA
 molecular_functionGO:0070612 histone methyltransferase activity (H2A-R3 specific) IDA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / complex / reaction
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / reaction / complex
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / complex / reaction
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction / complex
 ENSG00000169375 SIN3A / Q96ST3 / SIN3 transcription regulator family member A  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / reaction / complex
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / complex / reaction






 

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