ENSG00000126457


Homo sapiens

Features
Gene ID: ENSG00000126457
  
Biological name :PRMT1
  
Synonyms : PRMT1 / protein arginine methyltransferase 1 / Q99873
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 49675786
Gene end: 49689029
  
Corresponding Affymetrix probe sets: 1565016_at (Human Genome U133 Plus 2.0 Array)   206445_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431957
Ensembl peptide - ENSP00000484505
Ensembl peptide - ENSP00000437273
Ensembl peptide - ENSP00000434911
Ensembl peptide - ENSP00000433556
Ensembl peptide - ENSP00000433480
Ensembl peptide - ENSP00000432788
Ensembl peptide - ENSP00000432538
Ensembl peptide - ENSP00000432349
Ensembl peptide - ENSP00000432050
Ensembl peptide - ENSP00000375724
Ensembl peptide - ENSP00000406162
NCBI entrez gene - 3276     See in Manteia.
OMIM - 602950
RefSeq - XM_017026736
RefSeq - NM_001207042
RefSeq - NM_001536
RefSeq - NM_198318
RefSeq - XM_005258842
RefSeq - XM_017026734
RefSeq - XM_017026735
RefSeq Peptide - NP_938074
RefSeq Peptide - NP_001193971
RefSeq Peptide - NP_001527
swissprot - Q99873
swissprot - E9PQ98
swissprot - E9PMZ2
swissprot - E9PMW9
swissprot - E9PKG1
swissprot - E9PIX6
swissprot - E9PIE2
swissprot - E9PNR9
swissprot - A0A087X1W2
swissprot - H0YDE4
swissprot - H7C2I1
Ensembl - ENSG00000126457
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt1ENSDARG00000010246Danio rerio
 Prmt1ENSMUSG00000109324Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRMT8 / Q9NR22 / protein arginine methyltransferase 8ENSG0000011121877
PRMT3 / O60678 / protein arginine methyltransferase 3ENSG0000018523846
CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1ENSG0000014245334
PRMT6 / Q96LA8 / protein arginine methyltransferase 6ENSG0000019889031
PRMT2 / P55345 / protein arginine methyltransferase 2ENSG0000016031030


Protein motifs (from Interpro)
Interpro ID Name
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0016571 histone methylation IDA
 biological_processGO:0018216 peptidyl-arginine methylation IDA
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032259 methylation IEA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0043985 histone H4-R3 methylation IDA
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045653 negative regulation of megakaryocyte differentiation IDA
 biological_processGO:0046985 positive regulation of hemoglobin biosynthetic process ISS
 biological_processGO:1900745 positive regulation of p38MAPK cascade ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0034709 methylosome IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008170 N-methyltransferase activity TAS
 molecular_functionGO:0008276 protein methyltransferase activity IMP
 molecular_functionGO:0008327 methyl-CpG binding IDA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IMP
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044020 histone methyltransferase activity (H4-R3 specific) IMP
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IPI


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / reaction / complex
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / reaction / complex
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / reaction / complex
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / reaction / complex
 ENSG00000067955 CBFB / Q13951 / core-binding factor beta subunit  / complex / reaction
 ENSG00000159216 RUNX1 / Q01196 / runt related transcription factor 1  / reaction / complex
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / reaction / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction






 

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