ENSG00000108654


Homo sapiens

Features
Gene ID: ENSG00000108654
  
Biological name :DDX5
  
Synonyms : DDX5 / DEAD-box helicase 5 / P17844
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q23.3
Gene start: 64499616
Gene end: 64508199
  
Corresponding Affymetrix probe sets: 200033_at (Human Genome U133 Plus 2.0 Array)   225886_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463101
Ensembl peptide - ENSP00000463168
Ensembl peptide - ENSP00000463541
Ensembl peptide - ENSP00000463903
Ensembl peptide - ENSP00000463975
Ensembl peptide - ENSP00000464064
Ensembl peptide - ENSP00000464304
Ensembl peptide - ENSP00000464587
Ensembl peptide - ENSP00000464659
Ensembl peptide - ENSP00000465791
Ensembl peptide - ENSP00000485764
Ensembl peptide - ENSP00000225792
Ensembl peptide - ENSP00000403085
Ensembl peptide - ENSP00000440276
Ensembl peptide - ENSP00000462206
Ensembl peptide - ENSP00000462222
Ensembl peptide - ENSP00000462885
Ensembl peptide - ENSP00000464337
Ensembl peptide - ENSP00000464566
NCBI entrez gene - 1655     See in Manteia.
OMIM - 180630
RefSeq - NM_001320597
RefSeq - NM_004396
RefSeq - NM_001320595
RefSeq - NM_001320596
RefSeq Peptide - NP_001307526
RefSeq Peptide - NP_004387
RefSeq Peptide - NP_001307525
RefSeq Peptide - NP_001307524
swissprot - X6RLV5
swissprot - A0A0G2JLI4
swissprot - J3KRX8
swissprot - J3KRZ1
swissprot - J3KTA4
swissprot - J3KTQ4
swissprot - J3QKN9
swissprot - J3QLG9
swissprot - J3QR02
swissprot - J3QR62
swissprot - J3QRN5
swissprot - J3QRQ7
swissprot - J3QS79
swissprot - J3QS97
swissprot - J3QSF1
swissprot - K7EKV0
swissprot - P17844
Ensembl - ENSG00000108654
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ddx5ENSDARG00000038068Danio rerio
 DDX5ENSGALG00000003532Gallus gallus
 Ddx5ENSMUSG00000020719Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DDX17 / Q92841 / DEAD-box helicase 17ENSG0000010020170
DDX42 / Q86XP3 / DEAD-box helicase 42ENSG0000019823136
DDX43 / Q9NXZ2 / DEAD-box helicase 43ENSG0000008000733
DDX53 / Q86TM3 / DEAD-box helicase 53ENSG0000018473533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000629  ATP-dependent RNA helicase DEAD-box, conserved site
 IPR001650  Helicase, C-terminal
 IPR011545  DEAD/DEAH box helicase domain
 IPR012587  RNA helicase p68 repeat
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014014  RNA helicase, DEAD-box type, Q motif
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR033488  RNA helicase p68 (DDX5)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IMP
 biological_processGO:0000398 mRNA splicing, via spliceosome TAS
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IDA
 biological_processGO:0001837 epithelial to mesenchymal transition IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0009299 mRNA transcription IMP
 biological_processGO:0010501 RNA secondary structure unwinding IBA
 biological_processGO:0016049 cell growth NAS
 biological_processGO:0030509 BMP signaling pathway IMP
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0030521 androgen receptor signaling pathway IMP
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0045069 regulation of viral genome replication IEA
 biological_processGO:0045445 myoblast differentiation ISS
 biological_processGO:0045667 regulation of osteoblast differentiation ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IMP
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II ISS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:2001014 regulation of skeletal muscle cell differentiation ISS
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005681 spliceosomal complex IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071013 catalytic step 2 spliceosome IDA
 cellular_componentGO:0071141 SMAD protein complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003724 RNA helicase activity NAS
 molecular_functionGO:0003730 mRNA 3"-UTR binding IDA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035500 MH2 domain binding IPI
 molecular_functionGO:0036002 pre-mRNA binding IDA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IDA
 molecular_functionGO:0046332 SMAD binding IPI
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0050681 androgen receptor binding IDA
 molecular_functionGO:0070412 R-SMAD binding IPI
 molecular_functionGO:0070878 primary miRNA binding IDA
 molecular_functionGO:1990841 promoter-specific chromatin binding ISS


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors
mRNA Splicing - Major Pathway
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / complex / reaction
 ENSG00000126457 PRMT1 / Q99873 / protein arginine methyltransferase 1  / reaction / complex
 ENSG00000103275 UBE2I / P63279 / ubiquitin conjugating enzyme E2 I  / reaction
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / complex / reaction
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex / reaction
 ENSG00000142453 CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1  / reaction / complex
 ENSG00000116030 SUMO1 / P63165 / small ubiquitin-like modifier 1  / reaction / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000188612 SUMO2 / P61956 / small ubiquitin-like modifier 2  / reaction
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr