ENSG00000142453


Homo sapiens

Features
Gene ID: ENSG00000142453
  
Biological name :CARM1
  
Synonyms : CARM1 / coactivator associated arginine methyltransferase 1 / Q86X55
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 10871513
Gene end: 10923070
  
Corresponding Affymetrix probe sets: 212512_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468319
Ensembl peptide - ENSP00000467746
Ensembl peptide - ENSP00000467761
Ensembl peptide - ENSP00000325690
Ensembl peptide - ENSP00000340934
Ensembl peptide - ENSP00000464852
Ensembl peptide - ENSP00000465417
Ensembl peptide - ENSP00000467420
NCBI entrez gene - 10498     See in Manteia.
OMIM - 603934
RefSeq - XM_011527638
RefSeq - NM_199141
RefSeq - XM_005259708
RefSeq Peptide - NP_954592
swissprot - K7EQB9
swissprot - K7ERM3
swissprot - K7EIQ8
swissprot - Q86X55
swissprot - K7EK20
swissprot - K7EQA8
swissprot - K7EPK1
Ensembl - ENSG00000142453
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 carm1ENSDARG00000018698Danio rerio
 Carm1ENSMUSG00000032185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRMT3 / O60678 / protein arginine methyltransferase 3ENSG0000018523823
PRMT8 / Q9NR22 / protein arginine methyltransferase 8ENSG0000011121821
PRMT1 / Q99873 / protein arginine methyltransferase 1ENSG0000012645721
PRMT2 / P55345 / protein arginine methyltransferase 2ENSG0000016031021
PRMT6 / Q96LA8 / protein arginine methyltransferase 6ENSG0000019889020


Protein motifs (from Interpro)
Interpro ID Name
 IPR020989  Histone-arginine methyltransferase CARM1, N-terminal
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003420 regulation of growth plate cartilage chondrocyte proliferation IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016571 histone methylation ISS
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IEA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0032091 negative regulation of protein binding IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0034969 histone arginine methylation IEA
 biological_processGO:0034970 histone H3-R2 methylation IMP
 biological_processGO:0034971 histone H3-R17 methylation ISS
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060350 endochondral bone morphogenesis IEA
 biological_processGO:0071168 protein localization to chromatin IEA
 biological_processGO:1902415 regulation of mRNA binding IEA
 biological_processGO:2000171 negative regulation of dendrite development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0003713 transcription coactivator activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding TAS
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008276 protein methyltransferase activity ISS
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity IDA
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISS
 molecular_functionGO:0035642 histone methyltransferase activity (H3-R17 specific) ISS
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0070577 lysine-acetylated histone binding ISS


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
RMTs methylate histone arginines
Transcriptional regulation of white adipocyte differentiation
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / complex / reaction
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / complex / reaction
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / reaction / complex
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex / reaction
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / complex / reaction
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex / reaction






 

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