ENSG00000160310


Homo sapiens

Features
Gene ID: ENSG00000160310
  
Biological name :PRMT2
  
Synonyms : P55345 / PRMT2 / protein arginine methyltransferase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.3
Gene start: 46635167
Gene end: 46665124
  
Corresponding Affymetrix probe sets: 202098_s_at (Human Genome U133 Plus 2.0 Array)   210384_at (Human Genome U133 Plus 2.0 Array)   216069_at (Human Genome U133 Plus 2.0 Array)   221564_at (Human Genome U133 Plus 2.0 Array)   228722_at (Human Genome U133 Plus 2.0 Array)   228725_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406127
Ensembl peptide - ENSP00000397266
Ensembl peptide - ENSP00000407463
Ensembl peptide - ENSP00000482158
Ensembl peptide - ENSP00000411984
Ensembl peptide - ENSP00000291705
Ensembl peptide - ENSP00000335490
Ensembl peptide - ENSP00000347906
Ensembl peptide - ENSP00000380752
Ensembl peptide - ENSP00000380759
Ensembl peptide - ENSP00000380760
NCBI entrez gene - 3275     See in Manteia.
OMIM - 601961
RefSeq - XM_017028340
RefSeq - NM_001242864
RefSeq - NM_001242865
RefSeq - NM_001242866
RefSeq - NM_001286676
RefSeq - NM_001286677
RefSeq - NM_001286678
RefSeq - NM_001535
RefSeq - NM_206962
RefSeq - XM_005261111
RefSeq - XM_006723998
RefSeq - XM_006723999
RefSeq - XM_006724000
RefSeq - XM_017028339
RefSeq Peptide - NP_001229794
RefSeq Peptide - NP_001273606
RefSeq Peptide - NP_001273607
RefSeq Peptide - NP_001526
RefSeq Peptide - NP_996845
RefSeq Peptide - NP_001229793
RefSeq Peptide - NP_001229795
RefSeq Peptide - NP_001273605
swissprot - A0A0S2Z3N3
swissprot - H7C2H9
swissprot - P55345
swissprot - A0A087WYX1
swissprot - A8MXR3
Ensembl - ENSG00000160310
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prmt2ENSDARG00000063212Danio rerio
 Prmt2ENSMUSG00000020230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRMT3 / O60678 / protein arginine methyltransferase 3ENSG0000018523830
PRMT6 / Q96LA8 / protein arginine methyltransferase 6ENSG0000019889030
CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1ENSG0000014245329
PRMT1 / Q99873 / protein arginine methyltransferase 1ENSG0000012645726
PRMT8 / Q9NR22 / protein arginine methyltransferase 8ENSG0000011121826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR007848  Methyltransferase small domain
 IPR025799  Protein arginine N-methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006479 protein methylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0016571 histone methylation ISS
 biological_processGO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034969 histone arginine methylation IEA
 biological_processGO:0035246 peptidyl-arginine N-methylation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048588 developmental cell growth ISS
 biological_processGO:0060765 regulation of androgen receptor signaling pathway IDA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle ISS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0035189 Rb-E2F complex ISS
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008469 histone-arginine N-methyltransferase activity ISS
 molecular_functionGO:0016274 protein-arginine N-methyltransferase activity ISS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030331 estrogen receptor binding IPI
 molecular_functionGO:0033142 progesterone receptor binding IPI
 molecular_functionGO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IBA
 molecular_functionGO:0042054 histone methyltransferase activity IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042974 retinoic acid receptor binding IPI
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IPI
 molecular_functionGO:0046966 thyroid hormone receptor binding IPI
 molecular_functionGO:0050681 androgen receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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