ENSG00000140307


Homo sapiens

Features
Gene ID: ENSG00000140307
  
Biological name :GTF2A2
  
Synonyms : general transcription factor IIA subunit 2 / GTF2A2 / P52657
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.2
Gene start: 59638062
Gene end: 59657541
  
Corresponding Affymetrix probe sets: 202678_at (Human Genome U133 Plus 2.0 Array)   230376_at (Human Genome U133 Plus 2.0 Array)   243985_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000379373
Ensembl peptide - ENSP00000452648
Ensembl peptide - ENSP00000418574
Ensembl peptide - ENSP00000379376
Ensembl peptide - ENSP00000379375
Ensembl peptide - ENSP00000379372
NCBI entrez gene - 2958     See in Manteia.
OMIM - 600519
RefSeq - NM_001320929
RefSeq - NM_001320930
RefSeq - NM_004492
RefSeq Peptide - NP_004483
RefSeq Peptide - NP_001307858
RefSeq Peptide - NP_001307859
swissprot - P52657
swissprot - A0A0B4J1Z5
swissprot - A0A024R5Z5
swissprot - H0YK39
swissprot - A8MYR4
Ensembl - ENSG00000140307
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2a2ENSDARG00000053685Danio rerio
 GTF2A2ENSGALG00000003793Gallus gallus
 Gtf2a2ENSMUSG00000033543Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003194  Transcription initiation factor IIA, gamma subunit
 IPR009083  Transcription factor IIA, helical
 IPR009088  Transcription factor IIA, beta-barrel
 IPR015871  Transcription initiation factor IIA, gamma subunit, C-terminal
 IPR015872  Transcription initiation factor IIA, gamma subunit, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005669 transcription factor TFIID complex IDA
 cellular_componentGO:0005672 transcription factor TFIIA complex IEA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0001103 RNA polymerase II repressing transcription factor binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0017025 TBP-class protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex
 ENSG00000108654 DDX5 / P17844 / DEAD-box helicase 5  / reaction / complex
 ENSG00000129514 FOXA1 / P55317 / forkhead box A1  / complex / reaction
 ENSG00000112592 TBP / P20226 / TATA-box binding protein  / complex / reaction
 ENSG00000163161 ERCC3 / P19447 / ERCC excision repair 3, TFIIH core complex helicase subunit  / reaction
 ENSG00000142453 CARM1 / Q86X55 / coactivator associated arginine methyltransferase 1  / reaction / complex
 ENSG00000197265 GTF2E2 / P29084 / general transcription factor IIE subunit 2  / reaction / complex
 ENSG00000126457 PRMT1 / Q99873 / protein arginine methyltransferase 1  / reaction / complex
 ENSG00000153767 GTF2E1 / P29083 / general transcription factor IIE subunit 1  / complex / reaction
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / reaction / complex
 ENSG00000107485 GATA3 / P23771 / GATA binding protein 3  / complex / reaction
 ENSG00000137947 GTF2B / Q00403 / general transcription factor IIB  / complex / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / reaction / complex






 

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