ENSG00000137947


Homo sapiens

Features
Gene ID: ENSG00000137947
  
Biological name :GTF2B
  
Synonyms : general transcription factor IIB / GTF2B / Q00403
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p22.2
Gene start: 88852932
Gene end: 88891944
  
Corresponding Affymetrix probe sets: 208066_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359531
Ensembl peptide - ENSP00000415741
Ensembl peptide - ENSP00000402345
NCBI entrez gene - 2959     See in Manteia.
OMIM - 189963
RefSeq - NM_001514
RefSeq - XM_011541299
RefSeq Peptide - NP_001505
swissprot - B1APE2
swissprot - B1APE1
swissprot - Q00403
Ensembl - ENSG00000137947
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gtf2bENSDARG00000103578Danio rerio
 GTF2BENSGALG00000006205Gallus gallus
 Gtf2bENSMUSG00000028271Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000812  Transcription factor TFIIB
 IPR013137  Zinc finger, TFIIB-type
 IPR013150  Transcription factor TFIIB, cyclin-like domain
 IPR013763  Cyclin-like
 IPR023486  Transcription factor TFIIB, conserved site
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter TAS
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0042795 snRNA transcription by RNA polymerase II TAS
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0050434 positive regulation of viral transcription IMP
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IDA
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter IMP
 biological_processGO:0070897 DNA-templated transcriptional preinitiation complex assembly IEA
 biological_processGO:1904798 positive regulation of core promoter binding IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005669 transcription factor TFIID complex IDA
 cellular_componentGO:0005694 chromosome IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0097550 transcriptional preinitiation complex IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016407 acetyltransferase activity IDA
 molecular_functionGO:0017025 TBP-class protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163161 ERCC3 / P19447 / ERCC excision repair 3, TFIIH core complex helicase subunit  / reaction
 ENSG00000188342 GTF2F2 / P13984 / general transcription factor IIF subunit 2  / complex / reaction
 ENSG00000197265 GTF2E2 / P29084 / general transcription factor IIE subunit 2  / reaction / complex
 ENSG00000165417 GTF2A1 / P52655 / general transcription factor IIA subunit 1  / complex / reaction
 ENSG00000140307 GTF2A2 / P52657 / general transcription factor IIA subunit 2  / complex / reaction
 ENSG00000153767 GTF2E1 / P29083 / general transcription factor IIE subunit 1  / complex / reaction
 ENSG00000125651 GTF2F1 / P35269 / general transcription factor IIF subunit 1  / complex / reaction






 

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